The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"NADPH-cytochrome p450 Reductase; Chain A, domain 3
".
FunFam 11: Bifunctional cytochrome P450/NADPH--P450 reductase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
NADPH-hemoprotein reductase activity GO:0003958
Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.
|
8 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) P14779 (/IDA) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
8 | O08336 (/ISS) O08336 (/ISS) O08336 (/ISS) O08394 (/ISS) O08394 (/ISS) O08394 (/ISS) O08394 (/ISS) Q9Y8G7 (/ISS) |
|
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712
Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor.
|
8 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) P14779 (/IDA) |
|
Fatty acid binding GO:0005504
Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
7 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) |
|
FMN binding GO:0010181
Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
7 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
7 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) |
|
Flavin adenine dinucleotide binding GO:0050660
Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
|
7 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) |
|
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
FMN binding GO:0010181
Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |
|
Monooxygenase activity GO:0004497
Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.
|
2 | Q81NH4 (/ISS) Q81NH4 (/ISS) |
|
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
|
2 | Q81NH4 (/ISS) Q81NH4 (/ISS) |
|
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
|
1 | P14779 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P14779 (/IPI) |
|
Aromatase activity GO:0070330
Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
|
1 | P14779 (/IDA) |
There are 2 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
|
7 | O08336 (/IDA) O08336 (/IDA) O08336 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) O08394 (/IDA) |
|
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
3 | G4NG13 (/RCA) G4NG13 (/RCA) G4NG13 (/RCA) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
3 | G4NG13 (/IGC) G4NG13 (/IGC) G4NG13 (/IGC) |