The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: dynein heavy chain 2, axonemal

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
9 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
4 Q386I6 (/ISM) Q38B68 (/ISM) Q38B68 (/ISM) Q57YY8 (/ISM)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
4 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Dynein light chain binding GO:0045503
Interacting selectively and non-covalently with a light chain of the dynein complex.
4 A8I3X6 (/IPI) A8I5C3 (/IPI) A8ISA6 (/IPI) Q4AC22 (/IPI)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
3 Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
3 A0A0U1RVI8 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
3 A0A0U1RVI8 (/TAS) Q5LJP0 (/TAS) Q9GPN8 (/TAS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
2 E9Q8T7 (/IC) Q8WXX0 (/IC)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q4AC22 (/IDA)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
9 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
6 E9Q8T7 (/IMP) Q39575 (/IMP) Q4AC22 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
5 Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
4 Q386I6 (/ISM) Q38B68 (/ISM) Q38B68 (/ISM) Q57YY8 (/ISM)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
4 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
4 Q4AC22 (/IGI) Q9MBF8 (/IGI) Q9MBF8 (/IGI) Q9SMH3 (/IGI)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
2 E9Q8T7 (/IMP) Q9P2D7 (/IMP)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
1 Q8WXX0 (/IMP)
Epithelial cilium movement involved in extracellular fluid movement GO:0003351
The directed, self-propelled movement of cilia of epithelial cells. Depending on the type of cell, there may be one or many cilia per cell. This movement is usually coordinated between many epithelial cells, and serves to move extracellular fluid.
1 E9Q8T7 (/IMP)
Sperm axoneme assembly GO:0007288
The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
1 Q9P2D7 (/IMP)
Sperm axoneme assembly GO:0007288
The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
1 E9Q8T7 (/ISO)
Sperm axoneme assembly GO:0007288
The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.
1 Q63164 (/ISS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q9VJC6 (/IMP)
Retrograde axonal transport GO:0008090
The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.
1 Q19020 (/IMP)
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
1 Q9VZ77 (/IMP)
Neuron remodeling GO:0016322
The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development.
1 Q19020 (/IMP)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 E9Q8T7 (/ISO)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q63164 (/ISS)
Outer dynein arm assembly GO:0036158
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q39575 (/IMP)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q9P2D7 (/IDA)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 E9Q8T7 (/ISO)
Sperm competition GO:0046692
Any process that contributes to the success of sperm fertilization in multiply-mated females.
1 Q9VZ77 (/IMP)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 Q19020 (/IMP)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
1 Q19020 (/IGI)
Regulation of dendrite morphogenesis GO:0048814
Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
1 Q19020 (/IMP)
Establishment of spindle localization GO:0051293
The directed movement of the spindle to a specific location in the cell.
1 Q19020 (/IMP)
Establishment of meiotic spindle orientation GO:0051296
Any process that set the alignment of meiotic spindle relative to other cellular structures.
1 Q19020 (/IGI)
Establishment of meiotic spindle orientation GO:0051296
Any process that set the alignment of meiotic spindle relative to other cellular structures.
1 Q19020 (/IMP)
Maintenance of centrosome location GO:0051661
Any process in which a centrosome is maintained in a specific location within a cell and prevented from moving elsewhere.
1 Q19020 (/IMP)
Synaptic transmission, GABAergic GO:0051932
The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q19020 (/IGI)
Synaptic transmission, GABAergic GO:0051932
The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q19020 (/IMP)
Regulation of protein localization to synapse GO:1902473
Any process that modulates the frequency, rate or extent of protein localization to synapse.
1 Q19020 (/IMP)
Positive regulation of dense core granule transport GO:1904811
Any process that activates or increases the frequency, rate or extent of dense core granule transport.
1 Q19020 (/IMP)
Anterograde neuronal dense core vesicle transport GO:1990048
The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse.
1 Q19020 (/IMP)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
9 Q386I6 (/IDA) Q38B68 (/IDA) Q38B68 (/IDA) Q57WX6 (/IDA) Q57WX6 (/IDA) Q57YY8 (/IDA) Q580B5 (/IDA) Q9MBF8 (/IDA) Q9MBF8 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
9 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VWZ3 (/ISS) Q9VZ77 (/ISS)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
6 E9Q8T7 (/ISO) Q4Q1Y1 (/ISO) Q4Q2F4 (/ISO) Q4Q9Z6 (/ISO) Q4QB21 (/ISO) Q4QFY9 (/ISO)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
6 A8I3X6 (/IMP) Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
5 Q386I6 (/IDA) Q57WX6 (/IDA) Q57WX6 (/IDA) Q57YY8 (/IDA) Q8WXX0 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
5 Q4AC22 (/IDA) Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9P2D7 (/IDA) Q9SMH3 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
5 E9Q0T8 (/ISM) E9Q8T7 (/ISM) P0C6F1 (/ISM) P0C6F1 (/ISM) Q8BW94 (/ISM)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
4 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS) Q9P2D7 (/NAS)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
4 Q386I6 (/ISM) Q38B68 (/ISM) Q38B68 (/ISM) Q57YY8 (/ISM)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q19020 (/IDA) Q38B68 (/IDA) Q38B68 (/IDA)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
3 A0A0U1RVI8 (/TAS) Q5LJP0 (/TAS) Q9GPN8 (/TAS)
Intraciliary transport particle GO:0030990
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
2 Q38B68 (/IDA) Q38B68 (/IDA)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
2 P0C6F1 (/IDA) P0C6F1 (/IDA)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
2 E9Q8T7 (/IDA) Q9P2D7 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
2 E9Q0T8 (/ISO) E9Q8T7 (/ISO)
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
1 Q19020 (/IDA)
Spindle pole GO:0000922
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
1 Q19020 (/IDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q19020 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4Q1Y1 (/ISO)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
1 Q19020 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WXX0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 E9Q0T8 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 E9Q0T8 (/ISO)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q9P2D7 (/IMP)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
1 Q63164 (/ISS)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q19020 (/IDA)
Intraciliary transport particle GO:0030990
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
1 Q4Q1Y1 (/ISO)
Sperm flagellum GO:0036126
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.
1 E9Q8T7 (/ISO)
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