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CATH Superfamily 1.20.910.10

Heme oxygenase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Heme oxygenase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Bifunctional TH2 protein, mitochondrial

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aminopyrimidine aminohydrolase. [EC: 3.5.99.2]
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5- hydroxymethyl-2-methylpyrimidine + ammonia. (2) Thiamine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.
  • Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.
 4 A0A178UHC4 A0A178UHC4 F4KFT7 F4KFT7
Thiamine phosphate phosphatase. [EC: 3.1.3.100]
Thiamine phosphate + H(2)O = thiamine + phosphate.
  • The enzyme participates in the thiamine biosynthesis pathway in eukaryotes and a few prokaryotes.
  • These organisms lack EC 2.7.4.16 and need to convert thiamine phosphate to thiamine diphosphate, the active form of the vitamin, by first removing the phosphate group, followed by diphosphorylation by EC 2.7.6.2.
 4 A0A178UHC4 A0A178UHC4 F4KFT7 F4KFT7
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