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CATH Superfamily 1.20.840.10

Methyl-coenzyme M reductase, alpha/beta subunit, C-terminal

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Methyl-coenzyme M reductase, alpha/beta subunit, C-terminal
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Methyl-coenzyme M reductase I subunit beta

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Coenzyme-B sulfoethylthiotransferase. [EC: 2.8.4.1]
Methyl-CoM + CoB = CoM-S-S-CoB + methane.
  • This enzyme catalyzes the final step in methanogenesis, the biological production of methane.
  • This important anaerobic process is carried out only by methanogenic archaea.
  • The enzyme can also function in reverse, for anaerobic oxidation of methane.
  • The enzyme requires the hydroporphinoid nickel complex coenzyme F(430).
  • Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates.
  • The sulfide sulfur can be replaced by selenium but not by oxygen.
 5 A0A371NCH5 A0A371NCH5 O27236 O27236 P11560
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