The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytochrome Bc1 Complex; Chain C
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Cytochrome b

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
12 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P18946 (/IDA) P18946 (/IDA) P18946 (/IDA) P18946 (/IDA) P18946 (/IDA)
(2 more)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
11 P0C8L0 (/ISS) P0C8L0 (/ISS) Q2GGU7 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS)
(1 more)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
10 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00163 (/IDA) P00163 (/IDA) P24964 (/IDA) P24964 (/IDA) P24964 (/IDA)
Electron transfer activity GO:0009055
Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
9 Q2GGU7 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS)
Ubiquinone binding GO:0048039
Interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units.
5 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
3 P00159 (/IPI) P00159 (/IPI) P00159 (/IPI)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
2 P00156 (/NAS) P00156 (/NAS)
Electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity GO:0045153
Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex.
2 P00163 (/IDA) P00163 (/IDA)
Electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity GO:0045153
Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex.
1 Q85QA4 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
10 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00163 (/IDA) P00163 (/IDA) P24964 (/IDA) P24964 (/IDA) P24964 (/IDA)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
7 P18946 (/IEP) P18946 (/IEP) P18946 (/IEP) P18946 (/IEP) P18946 (/IEP) P18946 (/IEP) P18946 (/IEP)
Respiratory electron transport chain GO:0022904
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
7 P18946 (/NAS) P18946 (/NAS) P18946 (/NAS) P18946 (/NAS) P18946 (/NAS) P18946 (/NAS) P18946 (/NAS)
Respiratory electron transport chain GO:0022904
A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
5 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA)
Electron transport coupled proton transport GO:0015990
The transport of protons against an electrochemical gradient, using energy from electron transport.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Response to glucagon GO:0033762
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to organonitrogen compound GO:0010243
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Electron transport coupled proton transport GO:0015990
The transport of protons against an electrochemical gradient, using energy from electron transport.
3 P00159 (/IMP) P00159 (/IMP) P00159 (/IMP)
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to cobalamin GO:0033590
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalamin (vitamin B12) stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to glucagon GO:0033762
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
3 P00159 (/IDA) P00159 (/IDA) P00159 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Hyperosmotic salinity response GO:0042538
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
3 P00159 (/IMP) P00159 (/IMP) P00159 (/IMP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
3 P00159 (/IDA) P00159 (/IDA) P00159 (/IDA)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
3 P00159 (/IMP) P00159 (/IMP) P00159 (/IMP)
Response to calcium ion GO:0051592
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
3 P00159 (/IDA) P00159 (/IDA) P00159 (/IDA)
Response to hyperoxia GO:0055093
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating increased oxygen tension.
3 P00159 (/IEP) P00159 (/IEP) P00159 (/IEP)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 P00163 (/IMP) P00163 (/IMP)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 H9D0N6 (/ISO) Q85QA4 (/ISO)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 P0C8L0 (/ISS) P0C8L0 (/ISS)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 P00156 (/NAS) P00156 (/NAS)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 P00156 (/TAS) P00156 (/TAS)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 P18935 (/IMP) P18935 (/IMP)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
2 P00163 (/IMP) P00163 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
14 P00158 (/IDA) P00158 (/IDA) P00158 (/IDA) P00158 (/IDA) P00159 (/IDA) P00159 (/IDA) P00159 (/IDA) P18946 (/IDA) P18946 (/IDA) P18946 (/IDA)
(4 more)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
14 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00163 (/IDA) P00163 (/IDA) P18946 (/IDA) P18946 (/IDA) P18946 (/IDA)
(4 more)
Integral component of mitochondrial inner membrane GO:0031305
The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 P00158 (/IDA) P00158 (/IDA) P00158 (/IDA) P00158 (/IDA) P00159 (/IDA) P00159 (/IDA) P00159 (/IDA) P00163 (/IDA) P00163 (/IDA)
Plasma membrane respiratory chain complex III GO:0045276
A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species.
9 Q2GGU7 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS) Q2GKU4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 P00156 (/HDA) P00156 (/HDA) P00158 (/HDA) P00158 (/HDA) P00158 (/HDA) P00158 (/HDA) P00163 (/HDA) P00163 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P18946 (/IMP) P18946 (/IMP) P18946 (/IMP) P18946 (/IMP) P18946 (/IMP) P18946 (/IMP) P18946 (/IMP)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P18946 (/TAS) P18946 (/TAS) P18946 (/TAS) P18946 (/TAS) P18946 (/TAS) P18946 (/TAS) P18946 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA)
Integral component of mitochondrial membrane GO:0032592
The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA)
Intrinsic component of mitochondrial membrane GO:0098573
The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
5 P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA) P00157 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P00158 (/IDA) P00158 (/IDA) P00158 (/IDA) P00158 (/IDA)
Integral component of mitochondrial inner membrane GO:0031305
The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P00158 (/ISO) P00158 (/ISO) P00158 (/ISO) P00158 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
3 P00159 (/IDA) P00159 (/IDA) P00159 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P00159 (/IDA) P00159 (/IDA) P00159 (/IDA)
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
2 P0C8L0 (/ISS) P0C8L0 (/ISS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P00156 (/TAS) P00156 (/TAS)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
2 H9D0N6 (/ISO) Q85QA4 (/ISO)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
2 P0C8L0 (/ISS) P0C8L0 (/ISS)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
2 P00156 (/NAS) P00156 (/NAS)
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