The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Tyrosine-protein phosphatase non-receptor type 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 P26045 (/IPI) P29074 (/IPI) P29074 (/IPI) Q8BGS1 (/IPI) Q9JMC8 (/IPI) Q9WU22 (/IPI)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
4 P26045 (/IDA) Q8IRJ0 (/IDA) Q8WSF2 (/IDA) Q9W0R3 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
3 A2ALK8 (/ISS) Q8IRJ0 (/ISS) Q8WSF2 (/ISS)
Non-membrane spanning protein tyrosine phosphatase activity GO:0004726
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
2 P29074 (/TAS) P29074 (/TAS)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P26045 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 A2ALK8 (/ISO)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 A2ALK8 (/ISO)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 P26045 (/TAS)
Non-membrane spanning protein tyrosine phosphatase activity GO:0004726
Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate.
1 Q9WU22 (/IDA)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 Q9H329 (/TAS)
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
1 P26045 (/IDA)
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
1 A2ALK8 (/ISO)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q8BGS1 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 P26045 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 A2ALK8 (/ISO)

There are 80 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Establishment or maintenance of apical/basal cell polarity GO:0035088
Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.
12 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) A0T1Z4 (/IMP) A0T1Z5 (/IMP) B7Z0J2 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP)
(2 more)
Kidney development GO:0001822
The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Dorsal motor nucleus of vagus nerve development GO:0021744
The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Cellular protein-containing complex localization GO:0034629
A protein complex localization process that takes place at the cellular level; as a result, a protein complex is transported to, or maintained in, a specific location within a cell.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Maintenance of epithelial cell apical/basal polarity GO:0045199
The maintenance of the apicobasal polarity of an epithelial cell.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Positive regulation of Notch signaling pathway GO:0045747
Any process that activates or increases the frequency, rate or extent of the Notch signaling pathway.
8 A0A2R8QDM4 (/IEP) A0A2R8QU80 (/IEP) F1Q9F0 (/IEP) F1QVV9 (/IEP) F6NJ58 (/IEP) Q6NYK4 (/IEP) Q6PNC5 (/IEP) Q8AW25 (/IEP)
Embryonic eye morphogenesis GO:0048048
The process occurring in the embryo by which the anatomical structures of the post-embryonic eye are generated and organized.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Embryonic retina morphogenesis in camera-type eye GO:0060059
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Germ-band shortening GO:0007390
The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.
4 A0T1Z4 (/IMP) A0T1Z5 (/IMP) B7Z0J2 (/IMP) Q9VFU8 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
4 A0T1Z4 (/IMP) A0T1Z5 (/IMP) B7Z0J2 (/IMP) Q9VFU8 (/IMP)
Head involution GO:0008258
Movement of the anterior ectoderm to the interior of the embryo.
4 A0T1Z4 (/IMP) A0T1Z5 (/IMP) B7Z0J2 (/IMP) Q9VFU8 (/IMP)
Eye photoreceptor cell development GO:0042462
Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.
4 A0T1Z4 (/IMP) A0T1Z5 (/IMP) B7Z0J2 (/IMP) Q9VFU8 (/IMP)
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
4 A0T1Z4 (/IGI) A0T1Z5 (/IGI) B7Z0J2 (/IGI) Q9VFU8 (/IGI)
Amnioserosa maintenance GO:0046665
Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis.
4 A0T1Z4 (/IMP) A0T1Z5 (/IMP) B7Z0J2 (/IMP) Q9VFU8 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
3 P26045 (/TAS) P29074 (/TAS) P29074 (/TAS)
Mushroom body development GO:0016319
The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells.
3 Q8IRJ0 (/IMP) Q8WSF2 (/IMP) Q9W0R3 (/IMP)
Thermosensory behavior GO:0040040
Behavior that is dependent upon the sensation of temperature.
3 Q8IRJ0 (/IMP) Q8WSF2 (/IMP) Q9W0R3 (/IMP)
Central complex development GO:0048036
The process whose specific outcome is the progression of the central complex over time, from its formation to the mature structure. The central complex region of the insect brain is thought to be crucial for control of locomotive behavior. Located in the middle of the two protocerebral hemispheres, it comprises four neuropilar regions, the fan-shaped body, the ellipsoid body, the protocerebral bridge and the paired noduli.
3 Q8IRJ0 (/IMP) Q8WSF2 (/IMP) Q9W0R3 (/IMP)
Axon extension involved in axon guidance GO:0048846
The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
3 Q8IRJ0 (/IMP) Q8WSF2 (/IMP) Q9W0R3 (/IMP)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
2 Q8IRJ0 (/ISS) Q8WSF2 (/ISS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
2 Q8IRJ0 (/IDA) Q8WSF2 (/IDA)
Actomyosin structure organization GO:0031032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
2 Q8BGS1 (/IDA) Q9H329 (/IDA)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 P29074 (/TAS) P29074 (/TAS)
Liver regeneration GO:0097421
The regrowth of lost or destroyed liver.
2 A0A096MJT2 (/IEP) F1LQQ5 (/IEP)
Cell morphogenesis involved in differentiation GO:0000904
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
1 Q8BGS1 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
1 Q8BGS1 (/IMP)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 Q8BGS1 (/IMP)
Epithelial to mesenchymal transition GO:0001837
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
1 Q8BGS1 (/IMP)
Neural plate morphogenesis GO:0001839
The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.
1 Q8BGS1 (/IMP)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 Q8BGS1 (/IMP)
Epithelial cell morphogenesis GO:0003382
The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.
1 Q8BGS1 (/IMP)
Apical constriction GO:0003383
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.
1 Q8BGS1 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P26045 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 A2ALK8 (/ISO)
Substrate-dependent cell migration, cell attachment to substrate GO:0006931
The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions.
1 Q8BGS1 (/IMP)
Ectoderm development GO:0007398
The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.
1 Q8BGS1 (/IMP)
Endoderm development GO:0007492
The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.
1 Q8BGS1 (/IMP)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
1 Q8BGS1 (/IMP)
Mesoderm migration involved in gastrulation GO:0007509
The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.
1 Q8BGS1 (/IMP)
Unidimensional cell growth GO:0009826
The process in which a cell irreversibly increases in size in one
1 Q8BGS1 (/IDA)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
1 Q8BGS1 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9H329 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9JMC8 (/ISO)
Positive regulation of epithelial cell migration GO:0010634
Any process that activates or increases the frequency, rate or extent of epithelial cell migration.
1 Q8BGS1 (/IMP)
Negative regulation of cell-cell adhesion GO:0022408
Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.
1 Q8BGS1 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q8BGS1 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q8BGS1 (/IMP)
Actomyosin structure organization GO:0031032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.
1 Q9JMC8 (/ISO)
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
1 Q8BGS1 (/IDA)
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
1 Q8BGS1 (/IDA)
Somite rostral/caudal axis specification GO:0032525
The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.
1 Q8BGS1 (/IMP)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
1 Q9W0R3 (/IDA)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
1 Q9W0R3 (/IGI)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
1 Q9W0R3 (/IMP)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
1 P26045 (/TAS)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q9H329 (/IDA)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q9JMC8 (/ISO)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q9H329 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q9JMC8 (/ISO)
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
1 P26045 (/IDA)
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
1 A2ALK8 (/ISO)
Axial mesoderm development GO:0048318
The process whose specific outcome is the progression of the axial mesoderm over time, from its formation to the mature structure. The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord.
1 Q8BGS1 (/IMP)
Axial mesoderm morphogenesis GO:0048319
The process in which the anatomical structures of the axial mesoderm are generated and organized.
1 Q8BGS1 (/IMP)
Paraxial mesoderm development GO:0048339
The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.
1 Q8BGS1 (/IMP)
Embryonic foregut morphogenesis GO:0048617
The process in which the anatomical structures of the foregut are generated and organized, during the embryonic phase.
1 Q8BGS1 (/IMP)
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
1 P26045 (/IMP)
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
1 A2ALK8 (/ISO)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q9VFU8 (/IDA)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 Q9H329 (/IMP)
Positive regulation of keratinocyte migration GO:0051549
Any process that activates or increases the frequency, rate or extent of keratinocyte migration.
1 Q9JMC8 (/ISO)
Positive regulation of focal adhesion assembly GO:0051894
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
1 Q8BGS1 (/IMP)
Regulation of establishment of protein localization GO:0070201
Any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location.
1 Q8BGS1 (/IDA)
Left/right axis specification GO:0070986
The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
1 Q8BGS1 (/IMP)
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
1 Q8BGS1 (/IDA)
Regulation of membrane depolarization during action potential GO:0098902
Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential.
1 P26045 (/IDA)
Regulation of membrane depolarization during action potential GO:0098902
Any process that modulates the rate, frequency or extent of membrane depolarization during an action potential. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential.
1 A2ALK8 (/ISO)
Negative regulation of border follicle cell migration GO:1903687
Any process that stops, prevents or reduces the frequency, rate or extent of border follicle cell migration.
1 Q9W0R3 (/IMP)
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 P26045 (/IDA)
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 A2ALK8 (/ISO)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
8 A0A2R8QDM4 (/IMP) A0A2R8QU80 (/IMP) F1Q9F0 (/IMP) F1QVV9 (/IMP) F6NJ58 (/IMP) Q6NYK4 (/IMP) Q6PNC5 (/IMP) Q8AW25 (/IMP)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
8 A0A2R8QDM4 (/IPI) A0A2R8QU80 (/IPI) F1Q9F0 (/IPI) F1QVV9 (/IPI) F6NJ58 (/IPI) Q6NYK4 (/IPI) Q6PNC5 (/IPI) Q8AW25 (/IPI)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P26045 (/IDA) P29074 (/IDA) P29074 (/IDA) Q9H329 (/IDA)
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
4 A0T1Z4 (/IDA) A0T1Z5 (/IDA) B7Z0J2 (/IDA) Q9VFU8 (/IDA)
Septate junction GO:0005918
A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods.
4 A0T1Z4 (/IDA) A0T1Z5 (/IDA) B7Z0J2 (/IDA) Q9VFU8 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 A0T1Z4 (/IDA) A0T1Z5 (/IDA) B7Z0J2 (/IDA) Q9VFU8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 A2ALK8 (/ISO) Q9JMC8 (/ISO) Q9WU22 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q8IRJ0 (/ISS) Q8WSF2 (/ISS) Q9W0R3 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q8IRJ0 (/ISS) Q8WSF2 (/ISS) Q9W0R3 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q8IRJ0 (/HDA) Q8WSF2 (/HDA) Q9W0R3 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P29074 (/TAS) P29074 (/TAS) Q9HCM4 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q8BGS1 (/IDA) Q9H329 (/IDA) Q9HCM4 (/IDA)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
3 P26045 (/IDA) P29074 (/IDA) P29074 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P29074 (/TAS) P29074 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P29074 (/TAS) P29074 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9H329 (/IDA) Q9HCM4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8BGS1 (/ISO) Q9JMC8 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8BGS1 (/ISO) Q9JMC8 (/ISO)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 A2ALK8 (/ISO) Q9WU22 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9HCM4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BGS1 (/ISO)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 Q9VFU8 (/IDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 Q9H329 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P26045 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q8BGS1 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q8BGS1 (/IDA)
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
1 Q8BGS1 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9H329 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9JMC8 (/ISO)
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