The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 186: nesprin-1 isoform X3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
6 M9MRD1 (/IDA) M9MRD4 (/IDA) M9MRD6 (/IDA) M9MRF5 (/IDA) M9PC84 (/IDA) M9PCM8 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
6 M9MRD1 (/ISS) M9MRD4 (/ISS) M9MRD6 (/ISS) M9MRF5 (/ISS) M9PC84 (/ISS) M9PCM8 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 M9MRD1 (/IPI) M9MRD4 (/IPI) M9MRD6 (/IPI) M9MRF5 (/IPI) M9PC84 (/IPI) M9PCM8 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
6 M9MRD1 (/IPI) M9MRD4 (/IPI) M9MRD6 (/IPI) M9MRF5 (/IPI) M9PC84 (/IPI) M9PCM8 (/IPI)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus organization GO:0006997
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
6 M9MRD1 (/IGI) M9MRD4 (/IGI) M9MRD6 (/IGI) M9MRF5 (/IGI) M9PC84 (/IGI) M9PCM8 (/IGI)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Nuclear migration GO:0007097
The directed movement of the nucleus to a specific location within a cell.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Cytoplasmic transport, nurse cell to oocyte GO:0007303
The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Mesoderm development GO:0007498
The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.
6 M9MRD1 (/NAS) M9MRD4 (/NAS) M9MRD6 (/NAS) M9MRF5 (/NAS) M9PC84 (/NAS) M9PCM8 (/NAS)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Larval visceral muscle development GO:0007523
The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Female germline ring canal stabilization GO:0008335
Maintenance of the structural integrity of the ring canals connecting the female germline cyst.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Microtubule anchoring GO:0034453
Any process in which a microtubule is maintained in a specific location in a cell.
6 M9MRD1 (/IGI) M9MRD4 (/IGI) M9MRD6 (/IGI) M9MRF5 (/IGI) M9PC84 (/IGI) M9PCM8 (/IGI)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Endoplasmic reticulum localization GO:0051643
Any process in which endoplasmic reticulum is transported to, and/or maintained in, a specific location within the cell.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Mitochondrion localization GO:0051646
Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)
Nucleus localization GO:0051647
Any process in which the nucleus is transported to, and/or maintained in, a specific location within the cell.
6 M9MRD1 (/IGI) M9MRD4 (/IGI) M9MRD6 (/IGI) M9MRF5 (/IGI) M9PC84 (/IGI) M9PCM8 (/IGI)
Flight GO:0060361
Self-propelled movement of an organism from one location to another through the air, usually by means of active wing movement.
6 M9MRD1 (/IMP) M9MRD4 (/IMP) M9MRD6 (/IMP) M9MRF5 (/IMP) M9PC84 (/IMP) M9PCM8 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
6 M9MRD1 (/IDA) M9MRD4 (/IDA) M9MRD6 (/IDA) M9MRF5 (/IDA) M9PC84 (/IDA) M9PCM8 (/IDA)
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
6 M9MRD1 (/IDA) M9MRD4 (/IDA) M9MRD6 (/IDA) M9MRF5 (/IDA) M9PC84 (/IDA) M9PCM8 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 M9MRD1 (/IDA) M9MRD4 (/IDA) M9MRD6 (/IDA) M9MRF5 (/IDA) M9PC84 (/IDA) M9PCM8 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
6 M9MRD1 (/IDA) M9MRD4 (/IDA) M9MRD6 (/IDA) M9MRF5 (/IDA) M9PC84 (/IDA) M9PCM8 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
6 M9MRD1 (/IDA) M9MRD4 (/IDA) M9MRD6 (/IDA) M9MRF5 (/IDA) M9PC84 (/IDA) M9PCM8 (/IDA)
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