The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 147: utrophin isoform X2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 A0A1W2P8A5 (/IPI) A0A1W2P8G5 (/IPI) E9Q6R7 (/IPI) O08614 (/IPI) P46939 (/IPI) Q3TR59 (/IPI) Q3UYS4 (/IPI) Q6P6L2 (/IPI) Q810I5 (/IPI)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Vinculin binding GO:0017166
Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
3 A0A0G2JW60 (/IDA) G3V7L1 (/IDA) O55147 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 P46939 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P46939 (/IPI)
Vinculin binding GO:0017166
Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane.
1 P46939 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P46939 (/IPI)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Adult somatic muscle development GO:0007527
The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure.
8 A0A1W2P8A5 (/TAS) A0A1W2P8G5 (/TAS) E9Q6R7 (/TAS) O08614 (/TAS) Q3TR59 (/TAS) Q3UYS4 (/TAS) Q6P6L2 (/TAS) Q810I5 (/TAS)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
3 A0A0G2JW60 (/IDA) G3V7L1 (/IDA) O55147 (/IDA)
Response to denervation involved in regulation of muscle adaptation GO:0014894
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation.
3 A0A0G2JW60 (/IEP) G3V7L1 (/IEP) O55147 (/IEP)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 P46939 (/IMP)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
1 P46939 (/TAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 P46939 (/TAS)
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 O08614 (/IGI)
Regulation of sodium ion transmembrane transporter activity GO:2000649
Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity.
1 P46939 (/ISS)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
11 A0A0G2JW60 (/IDA) A0A1W2P8A5 (/IDA) A0A1W2P8G5 (/IDA) E9Q6R7 (/IDA) G3V7L1 (/IDA) O08614 (/IDA) O55147 (/IDA) Q3TR59 (/IDA) Q3UYS4 (/IDA) Q6P6L2 (/IDA)
(1 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Dystrophin-associated glycoprotein complex GO:0016010
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
8 A0A1W2P8A5 (/IDA) A0A1W2P8G5 (/IDA) E9Q6R7 (/IDA) O08614 (/IDA) Q3TR59 (/IDA) Q3UYS4 (/IDA) Q6P6L2 (/IDA) Q810I5 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
8 A0A1W2P8A5 (/ISO) A0A1W2P8G5 (/ISO) E9Q6R7 (/ISO) O08614 (/ISO) Q3TR59 (/ISO) Q3UYS4 (/ISO) Q6P6L2 (/ISO) Q810I5 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
8 A0A1W2P8A5 (/IDA) A0A1W2P8G5 (/IDA) E9Q6R7 (/IDA) O08614 (/IDA) Q3TR59 (/IDA) Q3UYS4 (/IDA) Q6P6L2 (/IDA) Q810I5 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
8 A0A1W2P8A5 (/IDA) A0A1W2P8G5 (/IDA) E9Q6R7 (/IDA) O08614 (/IDA) Q3TR59 (/IDA) Q3UYS4 (/IDA) Q6P6L2 (/IDA) Q810I5 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
3 A0A0G2JW60 (/IDA) G3V7L1 (/IDA) O55147 (/IDA)
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
3 A0A0G2JW60 (/IDA) G3V7L1 (/IDA) O55147 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P46939 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P46939 (/IDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 P46939 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P46939 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P46939 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P46939 (/TAS)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 P46939 (/IDA)
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
1 P46939 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P46939 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P46939 (/HDA)
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