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CATH Superfamily 1.20.58.480

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Tryptophan 2,3-dioxygenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tryptophan 2,3-dioxygenase activity GO:0004833
Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
 34 A7MBU6 (/ISS) A9FU01 (/ISS) B3MQP7 (/ISS) B3NVC6 (/ISS) B4H4U3 (/ISS) B4H4U3 (/ISS) B4IDV8 (/ISS) B4IDV8 (/ISS) B4JKK1 (/ISS) B4L629 (/ISS)
(24 more)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
 31 A7MBU6 (/ISS) A9FU01 (/ISS) B3MQP7 (/ISS) B3NVC6 (/ISS) B4H4U3 (/ISS) B4H4U3 (/ISS) B4IDV8 (/ISS) B4IDV8 (/ISS) B4JKK1 (/ISS) B4L629 (/ISS)
(21 more)
Tryptophan 2,3-dioxygenase activity GO:0004833
Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
 6 P20351 (/IDA) P21643 (/IDA) P48775 (/IDA) P48775 (/IDA) P48775 (/IDA) Q17P71 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
 6 P20351 (/IDA) P21643 (/IDA) P48775 (/IDA) P48775 (/IDA) P48775 (/IDA) Q17P71 (/IDA)
Tryptophan 2,3-dioxygenase activity GO:0004833
Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
 4 P20351 (/TAS) P48775 (/TAS) P48775 (/TAS) P48775 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 3 P48775 (/IPI) P48775 (/IPI) P48775 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 3 P48775 (/IPI) P48775 (/IPI) P48775 (/IPI)
Tryptophan 2,3-dioxygenase activity GO:0004833
Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine.
 2 P48776 (/ISO) P48776 (/ISO)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
 2 P48776 (/ISO) P48776 (/ISO)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
 2 P48776 (/ISO) P48776 (/ISO)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
 2 P48776 (/ISO) P48776 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 2 P48776 (/ISO) P48776 (/ISO)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
 1 P21643 (/IDA)
Oxygen binding GO:0019825
Interacting selectively and non-covalently with oxygen (O2).
 1 P21643 (/IDA)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
 35 A7MBU6 (/ISS) A9FU01 (/ISS) B3MQP7 (/ISS) B3NVC6 (/ISS) B4H4U3 (/ISS) B4H4U3 (/ISS) B4IDV8 (/ISS) B4IDV8 (/ISS) B4JKK1 (/ISS) B4L629 (/ISS)
(25 more)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
 16 A7MBU6 (/ISS) A9FU01 (/ISS) B4RUH2 (/ISS) P21643 (/ISS) P48776 (/ISS) P48776 (/ISS) Q2KIQ5 (/ISS) Q2KIQ5 (/ISS) Q5EBG2 (/ISS) Q5U4U6 (/ISS)
(6 more)
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
 5 P20351 (/IDA) P48775 (/IDA) P48775 (/IDA) P48775 (/IDA) Q17P71 (/IDA)
Tryptophan catabolic process GO:0006569
The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
 4 P20351 (/TAS) P48775 (/TAS) P48775 (/TAS) P48775 (/TAS)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
 4 P20351 (/IDA) P48775 (/IDA) P48775 (/IDA) P48775 (/IDA)
Tryptophan metabolic process GO:0006568
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
 2 P48776 (/ISO) P48776 (/ISO)
Tryptophan catabolic process to kynurenine GO:0019441
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.
 2 P48776 (/ISO) P48776 (/ISO)
Tryptophan catabolic process to acetyl-CoA GO:0019442
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.
 2 P48776 (/ISO) P48776 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
 2 P48776 (/ISO) P48776 (/ISO)
Tryptophan metabolic process GO:0006568
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.
 1 P21643 (/IDA)
Ommochrome biosynthetic process GO:0006727
The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.
 1 P20351 (/IMP)
Tryptophan catabolic process to acetyl-CoA GO:0019442
The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.
 1 P21643 (/IDA)
Compound eye pigmentation GO:0048072
Establishment of a pattern of pigment in the compound eye.
 1 P20351 (/TAS)
Kynurenine metabolic process GO:0070189
The chemical reactions and pathways involving kynurenine, the amino acid 3-(2-aminobenzoyl)-alanine.
 1 P20351 (/IMP)
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
 1 P20351 (/IMP)
Response to nitroglycerin GO:1904842
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitroglycerin stimulus.
 1 P21643 (/IEP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 3 P48775 (/TAS) P48775 (/TAS) P48775 (/TAS)