The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: Resistance to dieldrin, isoform H

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
4 P25123 (/TAS) P25123 (/TAS) P25123 (/TAS) P25123 (/TAS)
GABA-gated chloride ion channel activity GO:0022851
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Neurotransmitter receptor activity GO:0030594
Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Benzodiazepine receptor activity GO:0008503
Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.
1 Q75NA5 (/ISS)
Neurotransmitter receptor activity GO:0030594
Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.
1 Q9BLY8 (/ISS)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inter-male aggressive behavior GO:0002121
Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
4 P25123 (/IGI) P25123 (/IGI) P25123 (/IGI) P25123 (/IGI)
Sleep GO:0030431
Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Olfactory behavior GO:0042048
The behavior of an organism in response to an odor.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Regulation of circadian sleep/wake cycle GO:0042749
Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Regulation of olfactory learning GO:0090328
Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
4 P25123 (/IMP) P25123 (/IMP) P25123 (/IMP) P25123 (/IMP)
Regulation of neurotransmitter levels GO:0001505
Any process that modulates levels of neurotransmitter.
1 Q75NA5 (/ISS)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9BLY8 (/ISS)
Neurotransmitter transport GO:0006836
The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
1 Q75NA5 (/ISS)
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
1 Q75NA5 (/ISS)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P25123 (/ISS) P25123 (/ISS) P25123 (/ISS) P25123 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P25123 (/NAS) P25123 (/NAS) P25123 (/NAS) P25123 (/NAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Neuron projection membrane GO:0032589
The portion of the plasma membrane surrounding a neuron projection.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
4 P25123 (/IDA) P25123 (/IDA) P25123 (/IDA) P25123 (/IDA)
Integral component of synaptic vesicle membrane GO:0030285
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q75NA5 (/ISS)
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