The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Neurotransmitter-gated ion-channel transmembrane domain
".
FunFam 45: neuronal acetylcholine receptor subunit alpha-10
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Signaling receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q9GZZ6 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | B2RX82 (/IPI) |
|
Acetylcholine-gated cation-selective channel activity GO:0022848
Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
|
1 | B2RX82 (/IMP) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | Q9JLB5 (/IDA) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | Q9JLB5 (/IMP) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | B2RX82 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
2 | Q9GZZ6 (/TAS) Q9JLB5 (/TAS) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | Q9GZZ6 (/IGI) |
|
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
|
1 | B2RX82 (/ISO) |
|
Synaptic transmission, cholinergic GO:0007271
The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
1 | B2RX82 (/IMP) |
|
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
|
1 | Q9GZZ6 (/TAS) |
|
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
|
1 | B2RX82 (/IMP) |
|
Detection of mechanical stimulus involved in sensory perception of sound GO:0050910
The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
|
1 | B2RX82 (/IMP) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q9JLB5 (/IMP) |
|
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | B2RX82 (/ISO) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9GZZ6 (/TAS) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q9JLB5 (/IDA) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | B2RX82 (/ISO) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | Q9JLB5 (/IDA) |
|
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
|
1 | B2RX82 (/ISO) |
|
Cholinergic synapse GO:0098981
A synapse that uses acetylcholine as a neurotransmitter.
|
1 | Q9JLB5 (/IDA) |
|
Cholinergic synapse GO:0098981
A synapse that uses acetylcholine as a neurotransmitter.
|
1 | Q9JLB5 (/IMP) |
|
Cholinergic synapse GO:0098981
A synapse that uses acetylcholine as a neurotransmitter.
|
1 | B2RX82 (/ISO) |
|
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9JLB5 (/IDA) |
|
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | B2RX82 (/ISO) |
