The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Neurotransmitter-gated ion-channel transmembrane domain
".
FunFam 4: Gamma-aminobutyric acid receptor subunit beta-2 is...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 32 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
53 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(43 more) |
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
42 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(32 more) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
25 |
P28472 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
(15 more) |
GABA-gated chloride ion channel activity GO:0022851
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.
|
11 |
P08220 (/ISS)
P15431 (/ISS)
P15431 (/ISS)
P19019 (/ISS)
P28472 (/ISS)
P50571 (/ISS)
P50571 (/ISS)
P63079 (/ISS)
P63079 (/ISS)
P63080 (/ISS)
(1 more) |
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
|
9 | P08220 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P50571 (/ISS) P50571 (/ISS) |
GABA-gated chloride ion channel activity GO:0022851
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.
|
9 | P18505 (/IMP) P18505 (/IMP) P18505 (/IMP) P18505 (/IMP) P18505 (/IMP) P18505 (/IMP) P28472 (/IMP) P63080 (/IMP) P63080 (/IMP) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
7 | P15431 (/IMP) P15431 (/IMP) P28472 (/IMP) P63080 (/IMP) P63080 (/IMP) P63138 (/IMP) P63138 (/IMP) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | P63079 (/IPI) P63079 (/IPI) P63080 (/IPI) P63080 (/IPI) P63137 (/IPI) P63138 (/IPI) P63138 (/IPI) |
GABA-gated chloride ion channel activity GO:0022851
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.
|
7 | P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P28472 (/IDA) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
5 | P15431 (/IDA) P15431 (/IDA) P63080 (/IDA) P63080 (/IDA) P63137 (/IDA) |
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
4 | P15431 (/IDA) P15431 (/IDA) P63079 (/IDA) P63079 (/IDA) |
GABA-gated chloride ion channel activity GO:0022851
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.
|
4 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) |
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
3 | P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Inhibitory extracellular ligand-gated ion channel activity GO:0005237
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
|
2 | P63138 (/IMP) P63138 (/IMP) |
Anion channel activity GO:0005253
Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient.
|
2 | P15431 (/IDA) P15431 (/IDA) |
Anion channel activity GO:0005253
Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient.
|
2 | P50571 (/ISO) P50571 (/ISO) |
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
2 | P63079 (/IDA) P63079 (/IDA) |
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
2 | P63138 (/IMP) P63138 (/IMP) |
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
|
2 | P15431 (/IMP) P15431 (/IMP) |
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
|
2 | P50571 (/ISO) P50571 (/ISO) |
Ligand-gated ion channel activity GO:0015276
Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
|
2 | P15431 (/TAS) P15431 (/TAS) |
AP-2 adaptor complex binding GO:0035612
Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
|
2 | P63079 (/IPI) P63079 (/IPI) |
AP-2 adaptor complex binding GO:0035612
Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
|
2 | P63080 (/ISO) P63080 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P63080 (/ISO) P63080 (/ISO) |
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
|
2 | P15431 (/IPI) P15431 (/IPI) |
GABA receptor binding GO:0050811
Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor.
|
2 | P50571 (/ISO) P50571 (/ISO) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
2 | P15431 (/EXP) P15431 (/EXP) |
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
2 | P50571 (/ISO) P50571 (/ISO) |
Inhibitory extracellular ligand-gated ion channel activity GO:0005237
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels.
|
1 | P63137 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P28472 (/IPI) |
There are 39 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cellular response to histamine GO:0071420
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
|
55 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(45 more) |
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
|
45 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(35 more) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
27 |
P18505 (/IMP)
P18505 (/IMP)
P18505 (/IMP)
P18505 (/IMP)
P18505 (/IMP)
P18505 (/IMP)
P28472 (/IMP)
P47870 (/IMP)
P47870 (/IMP)
P47870 (/IMP)
(17 more) |
Inhibitory synapse assembly GO:1904862
The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.
|
26 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(16 more) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
24 |
P15431 (/TAS)
P15431 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
(14 more) |
Inhibitory synapse assembly GO:1904862
The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.
|
24 |
P28472 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
(14 more) |
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
20 |
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
(10 more) |
Synaptic transmission, GABAergic GO:0051932
The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
20 |
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
P47870 (/ISS)
(10 more) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
10 | P08220 (/ISS) P15431 (/ISS) P15431 (/ISS) P19019 (/ISS) P50571 (/ISS) P50571 (/ISS) P63079 (/ISS) P63079 (/ISS) P63080 (/ISS) P63080 (/ISS) |
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
9 | P08220 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P18505 (/ISS) P50571 (/ISS) P50571 (/ISS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
7 | P18505 (/TAS) P18505 (/TAS) P18505 (/TAS) P18505 (/TAS) P18505 (/TAS) P18505 (/TAS) P28472 (/TAS) |
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
|
7 | P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P28472 (/IDA) |
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Cellular response to histamine GO:0071420
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
|
5 | P15431 (/IDA) P15431 (/IDA) P28472 (/IDA) P63138 (/IDA) P63138 (/IDA) |
Cellular response to histamine GO:0071420
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
|
5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
|
5 | P28472 (/IMP) P63080 (/IMP) P63080 (/IMP) P63138 (/IMP) P63138 (/IMP) |
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
|
5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Synaptic transmission, GABAergic GO:0051932
The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
4 | P63079 (/IDA) P63079 (/IDA) P63138 (/IDA) P63138 (/IDA) |
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Synaptic transmission, GABAergic GO:0051932
The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
3 | P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
|
3 | P28472 (/ISS) P63079 (/ISS) P63079 (/ISS) |
Inner ear receptor cell development GO:0060119
The process whose specific outcome is the progression of an inner ear receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Innervation GO:0060384
The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Inhibitory synapse assembly GO:1904862
The aggregation, arrangement and bonding together of a set of components to form an inhibitory synapse.
|
3 | P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P15431 (/IMP) P15431 (/IMP) |
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P50571 (/ISO) P50571 (/ISO) |
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P15431 (/TAS) P15431 (/TAS) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
2 | P15431 (/IDA) P15431 (/IDA) |
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
2 | P50571 (/ISO) P50571 (/ISO) |
Central nervous system neuron development GO:0021954
The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.
|
2 | P15431 (/IEP) P15431 (/IEP) |
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
|
2 | P15431 (/IEP) P15431 (/IEP) |
Ovulation cycle GO:0042698
The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.
|
2 | P15431 (/IEP) P15431 (/IEP) |
Roof of mouth development GO:0060021
The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities.
|
2 | P63080 (/IMP) P63080 (/IMP) |
Inhibitory postsynaptic potential GO:0060080
A process that causes a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.
|
2 | P63080 (/IMP) P63080 (/IMP) |
There are 41 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
GABA-A receptor complex GO:1902711
A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).
|
57 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(47 more) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
55 |
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
D1LYT2 (/ISS)
(45 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
32 |
P18505 (/IDA)
P18505 (/IDA)
P18505 (/IDA)
P18505 (/IDA)
P18505 (/IDA)
P18505 (/IDA)
P28472 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
P47870 (/IDA)
(22 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
29 |
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P28472 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
(19 more) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
27 |
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P18505 (/TAS)
P28472 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
P47870 (/TAS)
(17 more) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
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20 |
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
P47870 (/HDA)
(10 more) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
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7 | P15431 (/IDA) P15431 (/IDA) P63079 (/IDA) P63079 (/IDA) P63080 (/IDA) P63080 (/IDA) P63137 (/IDA) |
GABA-A receptor complex GO:1902711
A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).
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7 | P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P18505 (/IDA) P28472 (/IDA) |
GABA-A receptor complex GO:1902711
A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).
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7 | P15431 (/IMP) P15431 (/IMP) P28472 (/IMP) P63080 (/IMP) P63080 (/IMP) P63138 (/IMP) P63138 (/IMP) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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5 | P15431 (/IMP) P15431 (/IMP) P28472 (/IMP) P63138 (/IMP) P63138 (/IMP) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
GABA-A receptor complex GO:1902711
A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).
|
5 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) P63137 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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4 | P15431 (/IDA) P15431 (/IDA) P63138 (/IDA) P63138 (/IDA) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
4 | P50571 (/ISO) P50571 (/ISO) P63080 (/ISO) P63080 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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3 | P19019 (/ISS) P63080 (/ISS) P63080 (/ISS) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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3 | P50571 (/ISO) P50571 (/ISO) P63137 (/ISO) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
3 | P63080 (/IMP) P63080 (/IMP) P63137 (/IMP) |
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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3 | P63079 (/IDA) P63079 (/IDA) P63137 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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2 | P15431 (/IDA) P15431 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
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2 | P50571 (/ISO) P50571 (/ISO) |
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
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2 | P15431 (/IDA) P15431 (/IDA) |
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
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2 | P50571 (/ISO) P50571 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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2 | P15431 (/IDA) P15431 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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2 | P50571 (/ISO) P50571 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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2 | P63138 (/IDA) P63138 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
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2 | P15431 (/IDA) P15431 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
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2 | P50571 (/ISO) P50571 (/ISO) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
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2 | P63079 (/IDA) P63079 (/IDA) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
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2 | P63080 (/ISO) P63080 (/ISO) |
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
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2 | P15431 (/IDA) P15431 (/IDA) |
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
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2 | P50571 (/ISO) P50571 (/ISO) |
Inhibitory synapse GO:0060077
A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
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2 | P63079 (/IDA) P63079 (/IDA) |
Inhibitory synapse GO:0060077
A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell.
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2 | P63080 (/ISO) P63080 (/ISO) |
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
2 | P15431 (/EXP) P15431 (/EXP) |
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P63079 (/IDA) P63079 (/IDA) |
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P63080 (/ISO) P63080 (/ISO) |
Integral component of postsynaptic specialization membrane GO:0099060
The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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2 | P63080 (/ISO) P63080 (/ISO) |
GABA receptor complex GO:1902710
A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor.
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2 | P63138 (/IDA) P63138 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P63137 (/ISO) |
GABA receptor complex GO:1902710
A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor.
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1 | P63137 (/ISO) |