The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Neurotransmitter-gated ion-channel transmembrane domain
".
FunFam 39: Ligand-Gated ion Channel
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G protein-coupled serotonin receptor activity GO:0004993
Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.
|
3 | H2L0B8 (/IDA) Q8MPU3 (/IDA) Q9GQ00 (/IDA) |
|
Extracellular ligand-gated ion channel activity GO:0005230
Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
|
3 | H2L0B8 (/IDA) Q8MPU3 (/IDA) Q9GQ00 (/IDA) |
|
Chloride channel activity GO:0005254
Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
|
3 | H2L0B8 (/IDA) Q8MPU3 (/IDA) Q9GQ00 (/IDA) |
There are 5 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | H2L0B8 (/IDA) Q8MPU3 (/IDA) Q9GQ00 (/IDA) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
3 | H2L0B8 (/IDA) Q8MPU3 (/IDA) Q9GQ00 (/IDA) |
|
Serotonin receptor signaling pathway GO:0007210
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
|
3 | H2L0B8 (/IMP) Q8MPU3 (/IMP) Q9GQ00 (/IMP) |
|
Behavioral response to starvation GO:0042595
Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.
|
3 | H2L0B8 (/IMP) Q8MPU3 (/IMP) Q9GQ00 (/IMP) |
|
Positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway GO:1904123
A serotonin receptor signaling pathway that results in positive regulation of fatty acid beta-oxidation.
|
1 | Q9GQ00 (/IMP) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | H2L0B8 (/ISS) Q8MPU3 (/ISS) Q9GQ00 (/ISS) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
3 | H2L0B8 (/IDA) Q8MPU3 (/IDA) Q9GQ00 (/IDA) |
