The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Neurotransmitter-gated ion-channel transmembrane domain
".
FunFam 32: gamma-aminobutyric acid receptor subunit epsilon
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Glycine-gated chloride ion channel activity GO:0022852
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts.
|
5 | Q8SWZ1 (/TAS) Q8SWZ1 (/TAS) Q8SWZ1 (/TAS) Q8SWZ1 (/TAS) Q8SWZ1 (/TAS) |
|
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
2 | A2AMW3 (/ISS) Q9JLE8 (/ISS) |
|
GABA-A receptor activity GO:0004890
Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.
|
1 | Q9ES14 (/IDA) |
|
GABA-gated chloride ion channel activity GO:0022851
Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.
|
1 | P78334 (/IDA) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | Q9ES14 (/EXP) |
|
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
|
1 | Q9ES14 (/IDA) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
5 | Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
5 | Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) |
|
Synaptic transmission, glycinergic GO:0060012
The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
5 | Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) Q8SWZ1 (/IGI) |
|
Negative regulation of neuronal action potential GO:1904456
Any process that stops, prevents or reduces the frequency, rate or extent of neuronal action potential.
|
5 | Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) Q8SWZ1 (/IMP) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | A2AMW3 (/ISS) Q9JLE8 (/ISS) |
|
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
2 | A2AMW3 (/ISS) Q9JLE8 (/ISS) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9ES14 (/TAS) |
|
Gamma-aminobutyric acid signaling pathway GO:0007214
The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.
|
1 | Q9ES14 (/IDA) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | Q9ES14 (/IEP) |
|
Negative regulation of chloride transport GO:2001226
Any process that stops, prevents or reduces the frequency, rate or extent of chloride transport.
|
1 | P78334 (/IDA) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | A2AMW3 (/ISS) Q9JLE8 (/ISS) |
|
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | Q9ES14 (/EXP) |
|
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
|
1 | Q9ES14 (/IDA) |
|
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9ES14 (/IDA) |
|
GABA-A receptor complex GO:1902711
A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor).
|
1 | P78334 (/IDA) |
