The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 27: Histamine-gated chloride channel subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histamine-gated chloride channel activity GO:0019182
Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts.
8 A1KYB3 (/IDA) A1KYB4 (/IDA) A1KYB5 (/IDA) E1JII9 (/IDA) Q8T9R9 (/IDA) Q8WS32 (/IDA) Q9VDU9 (/IDA) Q9VGI0 (/IDA)
Histamine-gated chloride channel activity GO:0019182
Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts.
4 A1KYB3 (/ISS) A1KYB4 (/ISS) A1KYB5 (/ISS) Q9VDU9 (/ISS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 A1KYB3 (/IDA) A1KYB4 (/IDA) A1KYB5 (/IDA) E1JII9 (/IDA) Q8T9R9 (/IDA) Q8WS32 (/IDA) Q9VDU9 (/IDA) Q9VGI0 (/IDA)
Thermotaxis GO:0043052
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
8 A1KYB3 (/IMP) A1KYB4 (/IMP) A1KYB5 (/IMP) E1JII9 (/IMP) Q8T9R9 (/IMP) Q8WS32 (/IMP) Q9VDU9 (/IMP) Q9VGI0 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
4 A1KYB3 (/IMP) A1KYB4 (/IMP) A1KYB5 (/IMP) Q9VDU9 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
4 A1KYB3 (/IMP) A1KYB4 (/IMP) A1KYB5 (/IMP) Q9VDU9 (/IMP)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
4 A1KYB3 (/IMP) A1KYB4 (/IMP) A1KYB5 (/IMP) Q9VDU9 (/IMP)
Response to ether GO:0045472
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.
4 A1KYB3 (/IMP) A1KYB4 (/IMP) A1KYB5 (/IMP) Q9VDU9 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 A1KYB3 (/ISM) A1KYB4 (/ISM) A1KYB5 (/ISM) E1JII9 (/ISM) Q8T9R9 (/ISM) Q8WS32 (/ISM) Q9VDU9 (/ISM) Q9VGI0 (/ISM)
Histamine-gated chloride channel complex GO:0019183
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts.
8 A1KYB3 (/IDA) A1KYB4 (/IDA) A1KYB5 (/IDA) E1JII9 (/IDA) Q8T9R9 (/IDA) Q8WS32 (/IDA) Q9VDU9 (/IDA) Q9VGI0 (/IDA)