The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Neurotransmitter-gated ion-channel transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 18: Glycine receptor subunit beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellularly glycine-gated ion channel activity GO:0016933
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P20781 (/IPI) P48167 (/IPI) P48168 (/IPI)
Extracellularly glycine-gated chloride channel activity GO:0016934
Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
2 P48168 (/IMP) Q6DC22 (/IMP)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 P48168 (/IPI)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 P20781 (/IDA)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 P48168 (/IMP)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 P48168 (/ISO)
Extracellularly glycine-gated ion channel activity GO:0016933
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
1 P20781 (/IDA)
Extracellularly glycine-gated ion channel activity GO:0016933
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
1 P48167 (/IMP)
Extracellularly glycine-gated ion channel activity GO:0016933
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
1 P48168 (/ISO)
Extracellularly glycine-gated ion channel activity GO:0016933
Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane.
1 P20781 (/TAS)
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
1 P48168 (/IDA)
Transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential GO:1904315
Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential.
1 P48168 (/IMP)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 P20781 (/TAS) P48167 (/TAS)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
2 P20781 (/ISS) P48168 (/ISS)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
1 P48167 (/IMP)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
1 P48168 (/ISO)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P48167 (/IDA)
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P48168 (/ISO)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
1 P48167 (/IDA)
Neuropeptide signaling pathway GO:0007218
The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.
1 P48168 (/ISO)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P48167 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P48168 (/ISO)
Acrosome reaction GO:0007340
The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
1 P48168 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P48167 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 P48168 (/ISO)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 P48168 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
1 P48168 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 Q6DC22 (/IMP)
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
1 P48168 (/IMP)
Neuromuscular process GO:0050905
Any process pertaining to the functions of the nervous and muscular systems of an organism.
1 P48168 (/IMP)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P20781 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P48168 (/ISO)
Synaptic transmission, glycinergic GO:0060012
The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P20781 (/IDA)
Synaptic transmission, glycinergic GO:0060012
The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P48168 (/IMP)
Synaptic transmission, glycinergic GO:0060012
The vesicular release of glycine from a presynapse, across a chemical synapse, the subsequent activation of glycine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 P48168 (/ISO)
Righting reflex GO:0060013
A reflex process in which an animal immediately tries to turn over after being placed in a supine position.
1 P48168 (/IMP)
Gamma-aminobutyric acid receptor clustering GO:0097112
The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.
1 P48168 (/IGI)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
1 P48167 (/IMP)
Chloride transmembrane transport GO:1902476
The process in which chloride is transported across a membrane.
1 P48168 (/ISO)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycine-gated chloride channel complex GO:0016935
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
4 P20781 (/ISS) P48168 (/ISS) Q6KBX4 (/ISS) Q9GJS9 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P20781 (/ISS) P48168 (/ISS) Q9GJS9 (/ISS)
Glycinergic synapse GO:0098690
A synapse that uses glycine as a neurotransmitter.
2 P20781 (/IDA) P48168 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P48168 (/ISA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P48167 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P48167 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P48167 (/IMP)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P48168 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P48168 (/ISA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P48168 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P48168 (/ISA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P20781 (/TAS)
Glycine-gated chloride channel complex GO:0016935
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
1 P48167 (/IDA)
Glycine-gated chloride channel complex GO:0016935
A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts.
1 P48168 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P20781 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P48168 (/ISO)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
1 P20781 (/TAS)
Glycinergic synapse GO:0098690
A synapse that uses glycine as a neurotransmitter.
1 P48168 (/IMP)
Glycinergic synapse GO:0098690
A synapse that uses glycine as a neurotransmitter.
1 P48168 (/ISO)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
1 P48168 (/IDA)
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