The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Formin, FH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Cytokinesis protein sepA

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O94532 (/IPI) P40450 (/IPI) P40450 (/IPI) P41832 (/IPI) P41832 (/IPI) Q10059 (/IPI)
Profilin binding GO:0005522
Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
4 P40450 (/IDA) P40450 (/IDA) P41832 (/IDA) P41832 (/IDA)
Profilin binding GO:0005522
Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin.
4 P40450 (/IMP) P40450 (/IMP) P41832 (/IMP) P41832 (/IMP)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
3 O94532 (/ISM) Q10059 (/ISM) Q10719 (/ISM)
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
2 Q5AAF4 (/IDA) Q5AL52 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 P41832 (/IPI) P41832 (/IPI)
F-bar domain binding GO:1990808
Interacting selectively and non-covalently with an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins.
1 Q10059 (/IPI)

There are 47 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Barbed-end actin filament capping GO:0051016
The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits.
5 P40450 (/IDA) P40450 (/IDA) P41832 (/IDA) P41832 (/IDA) Q10059 (/IDA)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
5 O94532 (/IMP) P40450 (/IMP) P40450 (/IMP) P41832 (/IMP) P41832 (/IMP)
Mitotic actomyosin contractile ring assembly GO:1903475
Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis.
5 O94532 (/IGI) P40450 (/IGI) P40450 (/IGI) P41832 (/IGI) P41832 (/IGI)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
4 P40450 (/IGI) P40450 (/IGI) P41832 (/IGI) P41832 (/IGI)
Formin-nucleated actin cable assembly GO:0070649
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
4 P40450 (/IDA) P40450 (/IDA) P41832 (/IDA) P41832 (/IDA)
Formin-nucleated actin cable assembly GO:0070649
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
4 P40450 (/IGI) P40450 (/IGI) P41832 (/IGI) P41832 (/IGI)
Formin-nucleated actin cable assembly GO:0070649
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
4 P40450 (/IMP) P40450 (/IMP) P41832 (/IMP) P41832 (/IMP)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
4 P40450 (/IGI) P40450 (/IGI) P41832 (/IGI) P41832 (/IGI)
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
2 P41832 (/IMP) P41832 (/IMP)
Septum digestion after cytokinesis GO:0000920
The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis.
2 Q5AAF4 (/IMP) Q5AL52 (/IMP)
Budding cell apical bud growth GO:0007118
Growth at the tip of a bud, in a cell that reproduces by budding.
2 P41832 (/IGI) P41832 (/IGI)
Budding cell apical bud growth GO:0007118
Growth at the tip of a bud, in a cell that reproduces by budding.
2 P41832 (/IMP) P41832 (/IMP)
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
2 P41832 (/IMP) P41832 (/IMP)
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
2 P41832 (/IDA) P41832 (/IDA)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
2 P40450 (/IDA) P40450 (/IDA)
Regulation of cellular protein localization GO:1903827
Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
2 P41832 (/IMP) P41832 (/IMP)
Protein localization to mitotic actomyosin contractile ring GO:1904498
Any protein localization to actomyosin contractile ring that is involved in mitotic cytokinesis.
2 O94532 (/IMP) Q10059 (/IMP)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
2 P41832 (/IMP) P41832 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 O94532 (/IGI)
Cellular bud site selection GO:0000282
The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.
1 Q5AL52 (/IMP)
Cytogamy GO:0000755
During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
1 Q10719 (/IMP)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 O94532 (/IMP)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
1 Q5AL52 (/IMP)
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
1 Q5AL52 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
1 Q5AL52 (/IMP)
Maintenance of cell polarity GO:0030011
The maintenance of established anisotropic intracellular organization or cell growth patterns.
1 Q5AL52 (/IMP)
Actin filament polymerization GO:0030041
Assembly of actin filaments by the addition of actin monomers to a filament.
1 Q10059 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5AL52 (/IMP)
Hyphal growth GO:0030448
Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
1 Q5AL52 (/IMP)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
1 Q10059 (/IDA)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
1 Q5AL52 (/IMP)
Filamentous growth of a population of unicellular organisms in response to chemical stimulus GO:0036171
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.
1 Q5AL52 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
1 Q5AL52 (/IMP)
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
1 Q5AL52 (/IMP)
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
1 O94532 (/ISM)
Actin nucleation GO:0045010
The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.
1 Q10059 (/TAS)
Golgi localization GO:0051645
Any process in which the Golgi is transported to, and/or maintained in, a specific location within the cell.
1 Q5AL52 (/IMP)
Actin cortical patch localization GO:0051666
Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.
1 Q5AL52 (/IMP)
Transitional endoplasmic reticulum polarization at cell division site GO:0061164
The endoplasmic reticulum polarization process that results in the structure being polarized at the site of future cell division.
1 Q10059 (/IMP)
Establishment or maintenance of cell polarity regulating cell shape GO:0071963
Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.
1 O94532 (/IMP)
Mitotic actomyosin contractile ring maintenance GO:1902406
Any actomyosin contractile ring maintenance that is involved in mitotic cell cycle.
1 Q10059 (/IMP)
Mitotic actomyosin contractile ring assembly GO:1903475
Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis.
1 Q10059 (/IMP)
Mitotic actomyosin contractile ring assembly actin filament organization GO:1903479
Any actin filament organization that is involved in mitotic actomyosin contractile ring assembly.
1 Q10059 (/IMP)
Negative regulation of actin filament binding GO:1904530
Any process that stops, prevents or reduces the frequency, rate or extent of actin filament binding.
1 Q10059 (/IDA)
Actin fusion focus assembly GO:1904600
The aggregation, arrangement and bonding together of a set of components to form an actin fusion focus.
1 Q10719 (/IMP)
Actin filament polymerization involved in mitotic actomyosin contractile ring assembly GO:1904670
Any actin filament polymerization that is involved in mitotic actomyosin contractile ring assembly.
1 Q10059 (/IMP)
Negative regulation of barbed-end actin filament capping GO:2000813
Any process that stops, prevents or reduces the frequency, rate or extent of barbed-end actin filament capping.
1 Q10059 (/IDA)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
6 P40450 (/IDA) P40450 (/IDA) P41832 (/IDA) P41832 (/IDA) Q5AAF4 (/IDA) Q5AL52 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
6 O94532 (/IDA) P40450 (/IDA) P40450 (/IDA) P41832 (/IDA) P41832 (/IDA) Q10059 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
4 O94532 (/IDA) P41832 (/IDA) P41832 (/IDA) Q10719 (/IDA)
Incipient cellular bud site GO:0000131
The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
3 P41832 (/IDA) P41832 (/IDA) Q5AL52 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O94532 (/HDA) Q10059 (/HDA) Q10719 (/HDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
3 P41832 (/IDA) P41832 (/IDA) Q5AL52 (/IDA)
Polarisome GO:0000133
Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.
2 P41832 (/IDA) P41832 (/IDA)
Polarisome GO:0000133
Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.
2 P41832 (/IPI) P41832 (/IPI)
Cellular bud neck contractile ring GO:0000142
A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.
2 Q5AAF4 (/IDA) Q5AL52 (/IDA)
Hyphal tip GO:0001411
The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.
2 Q5AAF4 (/IDA) Q5AL52 (/IDA)
Prospore membrane GO:0005628
The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe.
2 P41832 (/HDA) P41832 (/HDA)
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.
2 O94532 (/IDA) Q10059 (/IDA)
Actin filament GO:0005884
A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.
2 P41832 (/IDA) P41832 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P41832 (/HDA) P41832 (/HDA)
Cell septum GO:0030428
A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.
2 Q5AAF4 (/IDA) Q5AL52 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
2 Q10059 (/HDA) Q10719 (/HDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
2 P41832 (/HDA) P41832 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q10059 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q10719 (/HDA)
Mating projection GO:0005937
The projection formed by unicellular fungi in response to mating pheromone.
1 Q10719 (/IDA)
Spitzenkorper GO:0031521
Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.
1 Q5AL52 (/IDA)
Cellular bud neck split septin rings GO:0032177
Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated.
1 Q5AAF4 (/IDA)
Cell cortex of cell tip GO:0051285
The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
1 O94532 (/IDA)
Medial cortical node GO:0071341
A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis.
1 Q10059 (/IDA)
Mitotic actomyosin contractile ring GO:0110085
A cytoskeletal structure composed of actin filaments, myosin, and myosin-associated proteins that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the mitotic spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two future daughter cells. In animal cells, the mitotic contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the mitotic contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.
1 Q10059 (/IDA)
Actomyosin contractile ring, proximal layer GO:0120104
The region of the actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located.
1 Q10059 (/IDA)
Actin fusion focus GO:1990819
A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.
1 Q10719 (/IDA)
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