The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Histone lysine demethylase PHF8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
5 E6ZGB4 (/ISS) P0CH95 (/ISS) Q6P949 (/ISS) Q80TJ7 (/ISS) Q9WTU0 (/ISS)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
5 E6ZGB4 (/ISS) P0CH95 (/ISS) Q6P949 (/ISS) Q80TJ7 (/ISS) Q9WTU0 (/ISS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
4 E6ZGB4 (/ISS) Q6P949 (/ISS) Q80TJ7 (/ISS) Q9WTU0 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q6P949 (/ISS) Q80TJ7 (/ISS) Q9WTU0 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 O75151 (/IDA) Q9UPP1 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 Q80TJ7 (/ISO) Q9WTU0 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O75151 (/IPI) Q9UPP1 (/IPI)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 O75151 (/IDA) Q9UPP1 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q80TJ7 (/ISO) Q9WTU0 (/ISO)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
2 O75151 (/IDA) Q9UPP1 (/IDA)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
2 Q80TJ7 (/ISO) Q9WTU0 (/ISO)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
2 O75151 (/IDA) Q9UPP1 (/IDA)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
2 Q80TJ7 (/ISO) Q9WTU0 (/ISO)
Histone demethylase activity (H4-K20 specific) GO:0035575
Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Histone demethylase activity (H3-K36 specific) GO:0051864
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9UPP1 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q80TJ7 (/ISO)
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
1 Q9UPP1 (/IDA)
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
1 Q80TJ7 (/ISO)
2-oxoglutarate-dependent dioxygenase activity GO:0016706
Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor.
1 Q80TJ7 (/ISS)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q9UPP1 (/IDA)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q80TJ7 (/ISO)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q80TJ7 (/ISS)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q9UPP1 (/TAS)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
1 Q9WTU0 (/TAS)
Histone demethylase activity (H4-K20 specific) GO:0035575
Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.
1 Q9UPP1 (/IDA)
Histone demethylase activity (H4-K20 specific) GO:0035575
Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.
1 Q80TJ7 (/ISO)
Histone demethylase activity (H3-K36 specific) GO:0051864
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.
1 Q9UPP1 (/IDA)
Histone demethylase activity (H3-K36 specific) GO:0051864
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 36) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 36 of the histone H3 protein.
1 Q80TJ7 (/ISO)
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
1 Q9UPP1 (/IDA)
Histone demethylase activity (H3-K27 specific) GO:0071558
Catalysis of the removal of a methyl group from lysine at position 27 of the histone H3 protein.
1 Q80TJ7 (/ISO)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of chromatin silencing at rDNA GO:0061188
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.
4 P0CH95 (/ISS) Q6P949 (/ISS) Q80TJ7 (/ISS) Q9WTU0 (/ISS)
Protein demethylation GO:0006482
The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
3 E6ZGB4 (/ISS) Q6P949 (/ISS) Q9WTU0 (/ISS)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 Q80TJ7 (/ISS) Q9UPP1 (/ISS)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
2 Q9UPP1 (/IDA) Q9WTU0 (/IDA)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Histone H4-K20 demethylation GO:0035574
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P0CH95 (/IMP) Q9UPP1 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Positive regulation of transcription by RNA polymerase I GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Negative regulation of chromatin silencing at rDNA GO:0061188
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.
2 Q80TJ7 (/ISO) Q9WTU0 (/ISO)
Histone H3-K36 demethylation GO:0070544
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
2 P0CH95 (/ISS) Q80TJ7 (/ISS)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
1 Q9UPP1 (/IMP)
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
1 Q80TJ7 (/ISO)
Liver development GO:0001889
The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
1 O75151 (/TAS)
Protein demethylation GO:0006482
The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 O75151 (/IDA)
Protein demethylation GO:0006482
The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
1 Q9WTU0 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P0CH95 (/IMP)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
1 Q80TJ7 (/ISO)
Histone H4-K20 demethylation GO:0035574
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.
1 Q9UPP1 (/IDA)
Histone H4-K20 demethylation GO:0035574
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.
1 Q80TJ7 (/ISO)
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
1 P0CH95 (/IGI)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9UPP1 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q80TJ7 (/ISO)
Positive regulation of transcription by RNA polymerase I GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
1 Q9UPP1 (/IDA)
Positive regulation of transcription by RNA polymerase I GO:0045943
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I.
1 Q80TJ7 (/ISO)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
1 P0CH95 (/IGI)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
1 P0CH95 (/IMP)
Primitive erythrocyte differentiation GO:0060319
Erythrocyte differentiation which occurs as part of the process of primitive hemopoiesis.
1 P0CH95 (/IMP)
Negative regulation of chromatin silencing at rDNA GO:0061188
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.
1 Q9UPP1 (/IDA)
Negative regulation of chromatin silencing at rDNA GO:0061188
Any process that decreases the rate, frequency, or extent of the repression of transcription of ribosomal DNA by altering the structure of chromatin.
1 O75151 (/IMP)
Histone H3-K36 demethylation GO:0070544
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
1 Q9UPP1 (/IDA)
Histone H3-K36 demethylation GO:0070544
The modification of histone H3 by the removal of a methyl group from lysine at position 36 of the histone.
1 Q80TJ7 (/ISO)
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
1 Q9UPP1 (/IDA)
Histone H3-K27 demethylation GO:0071557
The modification of histone H3 by the removal of a methyl group from lysine at position 27 of the histone.
1 Q80TJ7 (/ISO)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
4 P0CH95 (/ISS) Q6P949 (/ISS) Q80TJ7 (/ISS) Q9WTU0 (/ISS)
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
3 E6ZGB4 (/ISS) Q6P949 (/ISS) Q9WTU0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 H0Y3N9 (/IDA) H0Y589 (/IDA) Q9UPP1 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
3 H0Y3N9 (/IDA) H0Y589 (/IDA) Q9UPP1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 O75151 (/TAS) Q9UPP1 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 O75151 (/IDA) Q9UPP1 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 Q80TJ7 (/ISO) Q9WTU0 (/ISO)
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
1 O75151 (/IDA)
Kinetochore GO:0000776
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
1 Q9WTU0 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9UPP1 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80TJ7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q80TJ7 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O75151 (/TAS)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q80TJ7 (/ISO)
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