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CATH Superfamily 1.20.58.1000

Metal-sensitive repressor, helix protomer

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metal-sensitive repressor, helix protomer
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Metal-sensitive repressor, helix protomer

This superfamily includes metal-sensitive repressors, involved in resistance to metal ions. The overall protomer fold consists of three alpha-helices of varying lengths, organised in a closed tetrameric assembly. Members of this superfamily bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression PMID:17143269,PMID:20395270,PMID:17186148,PMID:17293508,PMID:16956381.

PFAM:PF02583, INTERPRO:IPR003735,DOI:10.1074/jbc.M112.352740

GO Diversity

Unique GO annotations
11 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
9685 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 19
Domain clusters (>95% seq id): 7
Domain clusters (>35% seq id): 4
Unique PDBs: 8
Alignments
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC:
Unique GO: 11
Taxonomy
Unique Species: 9685