The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Bicelle-embedded integrin alpha(iib) transmembrane segment
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Integrin, alpha 10

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
5 E9PXZ3 (/ISO) E9Q6R1 (/ISO) P61622 (/ISO) Q14BL5 (/ISO) Q8BM12 (/ISO)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
2 O75578 (/TAS) Q9UKX5 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 Q9V7A4 (/ISS) Q9W1M8 (/ISS)
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
2 O75578 (/IMP) Q9UKX5 (/IMP)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 Q9UKX5 (/IMP)
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
1 P61622 (/ISO)
Collagen receptor activity GO:0038064
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 Q9UKX5 (/IMP)
Collagen receptor activity GO:0038064
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P61622 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 O44386 (/IPI)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
5 E9PXZ3 (/ISO) E9Q6R1 (/ISO) P61622 (/ISO) Q14BL5 (/ISO) Q8BM12 (/ISO)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
5 O44386 (/TAS) O75578 (/TAS) Q9UKX5 (/TAS) Q9V7A4 (/TAS) Q9W1M8 (/TAS)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
5 E9PXZ3 (/ISO) E9Q6R1 (/ISO) P61622 (/ISO) Q14BL5 (/ISO) Q8BM12 (/ISO)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
4 O44386 (/ISS) Q27977 (/ISS) Q9V7A4 (/ISS) Q9W1M8 (/ISS)
Oocyte growth GO:0001555
The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
3 O44386 (/IMP) Q9V7A4 (/IMP) Q9W1M8 (/IMP)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
3 O44386 (/TAS) Q9V7A4 (/TAS) Q9W1M8 (/TAS)
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
2 P61622 (/IMP) Q9UKX5 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
2 O75578 (/IMP) Q9UKX5 (/IMP)
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 O75578 (/IMP) Q9UKX5 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
2 O75578 (/TAS) Q9UKX5 (/TAS)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
1 Q9UKX5 (/HDA)
Pericardium morphogenesis GO:0003344
The process in which the anatomical structure of the pericardium is generated and organized.
1 O44386 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 O44386 (/IMP)
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
1 P61622 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q9UKX5 (/TAS)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 O44386 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 O44386 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O44386 (/IMP)
Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
1 O44386 (/IMP)
Midgut development GO:0007494
The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
1 O44386 (/TAS)
Larval heart development GO:0007508
The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.
1 O44386 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q9UKX5 (/TAS)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 O44386 (/NAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 O44386 (/NAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 O44386 (/TAS)
Short-term memory GO:0007614
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.
1 O44386 (/TAS)
Olfactory learning GO:0008355
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.
1 O44386 (/NAS)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
1 O44386 (/ISS)
Calcium-dependent cell-matrix adhesion GO:0016340
The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction.
1 O44386 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 O44386 (/TAS)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 O44386 (/IMP)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q9UKX5 (/IMP)
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 P61622 (/ISO)
Dorsal trunk growth, open tracheal system GO:0035001
Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.
1 O44386 (/IMP)
Collagen-activated signaling pathway GO:0038065
A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9UKX5 (/IMP)
Collagen-activated signaling pathway GO:0038065
A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P61622 (/ISO)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 O44386 (/NAS)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 O44386 (/IMP)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 O44386 (/IMP)
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
1 O44386 (/IGI)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
1 O44386 (/IMP)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integrin alpha10-beta1 complex GO:0034680
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
4 E9PXZ3 (/ISO) E9Q6R1 (/ISO) Q14BL5 (/ISO) Q8BM12 (/ISO)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
3 O44386 (/ISS) Q9V7A4 (/ISS) Q9W1M8 (/ISS)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
3 O44386 (/NAS) Q9V7A4 (/NAS) Q9W1M8 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O44386 (/ISS) Q27977 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O75578 (/TAS) Q9UKX5 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 O44386 (/ISS) Q27977 (/ISS)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
2 O75578 (/TAS) Q9UKX5 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9V7A4 (/ISS) Q9W1M8 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O44386 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q9UKX5 (/HDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 Q9UKX5 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P61622 (/ISO)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
1 O44386 (/IDA)
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
1 O44386 (/IPI)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 O44386 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q27977 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9UKX5 (/HDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O44386 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 O44386 (/IDA)
Integrin alpha10-beta1 complex GO:0034680
An integrin complex that comprises one alpha10 subunit and one beta1 subunit.
1 O75578 (/IDA)
Integrin alpha11-beta1 complex GO:0034681
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
1 Q9UKX5 (/IDA)
Integrin alpha11-beta1 complex GO:0034681
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
1 P61622 (/ISO)