The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Single helix bin
".
FunFam 1: rho-associated protein kinase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
15 |
A0A0R4IHT4 (/IPI)
F1PU60 (/IPI)
O75116 (/IPI)
O75116 (/IPI)
P70335 (/IPI)
P70336 (/IPI)
Q13464 (/IPI)
Q62868 (/IPI)
Q90Y37 (/IPI)
Q961D4 (/IPI)
(5 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
9 | O75116 (/IDA) O75116 (/IDA) Q13464 (/IDA) Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JC83 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
8 | O75116 (/ISS) O75116 (/ISS) Q961D4 (/ISS) Q9U779 (/ISS) Q9VXE3 (/ISS) X2JC83 (/ISS) X2JE40 (/ISS) X2JKQ8 (/ISS) |
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
|
6 | Q961D4 (/IPI) Q9U779 (/IPI) Q9VXE3 (/IPI) X2JC83 (/IPI) X2JE40 (/IPI) X2JKQ8 (/IPI) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
5 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) Q28021 (/TAS) Q9U779 (/TAS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | O75116 (/NAS) O75116 (/NAS) Q13464 (/NAS) Q63644 (/NAS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
|
3 | O75116 (/NAS) O75116 (/NAS) Q13464 (/NAS) |
Tau-protein kinase activity GO:0050321
Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein.
|
3 | O75116 (/NAS) O75116 (/NAS) Q13464 (/NAS) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | O75116 (/HDA) O75116 (/HDA) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | P70336 (/IDA) Q28021 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
2 | O75116 (/NAS) O75116 (/NAS) |
Rho-dependent protein serine/threonine kinase activity GO:0072518
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Rho-dependent protein serine/threonine kinase activity GO:0072518
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Rho-dependent protein serine/threonine kinase activity GO:0072518
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho.
|
2 | O75116 (/TAS) O75116 (/TAS) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | P70336 (/ISO) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q13464 (/TAS) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q62868 (/TAS) |
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
|
1 | Q63644 (/IMP) |
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
|
1 | P70335 (/ISO) |
Rho-dependent protein serine/threonine kinase activity GO:0072518
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires binding of the GTPase Rho.
|
1 | Q13464 (/IDA) |
There are 232 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
8 | F1MF50 (/IMP) Q8MIT6 (/IMP) Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
8 | A0A0R4IHT4 (/IMP) Q90Y37 (/IMP) Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Mitotic spindle elongation GO:0000022
The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
|
6 | Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JC83 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA) |
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
6 | Q961D4 (/TAS) Q9U779 (/TAS) Q9VXE3 (/TAS) X2JC83 (/TAS) X2JE40 (/TAS) X2JKQ8 (/TAS) |
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Apical constriction involved in gastrulation GO:0003384
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
6 | Q961D4 (/IPI) Q9U779 (/IPI) Q9VXE3 (/IPI) X2JC83 (/IPI) X2JE40 (/IPI) X2JKQ8 (/IPI) |
Ovarian nurse cell to oocyte transport GO:0007300
Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Nurse cell nucleus anchoring GO:0007302
Attachment of the nurse cell nucleus to the plasma membrane.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Oocyte axis specification GO:0007309
The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
|
6 | Q961D4 (/TAS) Q9U779 (/TAS) Q9VXE3 (/TAS) X2JC83 (/TAS) X2JE40 (/TAS) X2JKQ8 (/TAS) |
Female germline ring canal stabilization GO:0008335
Maintenance of the structural integrity of the ring canals connecting the female germline cyst.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
6 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) Q13464 (/IMP) Q62868 (/IMP) Q63644 (/IMP) |
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Cortical protein anchoring GO:0032065
A process in which a protein or protein complex is maintained in a specific location in the cell cortex.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of actin filament bundle assembly GO:0032231
Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.
|
6 | Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JC83 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI) |
Regulation of actin filament bundle assembly GO:0032231
Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Nuclear axial expansion GO:0035191
The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Imaginal disc-derived wing hair organization GO:0035317
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
|
6 | Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JC83 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI) |
Imaginal disc-derived wing hair organization GO:0035317
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Establishment of ommatidial planar polarity GO:0042067
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
|
6 | Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JC83 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA) |
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Oocyte development GO:0048599
The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
|
6 | Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JC83 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI) |
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
6 | Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JC83 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI) |
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of myoblast fusion GO:1901739
Any process that modulates the frequency, rate or extent of myoblast fusion.
|
6 | Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JC83 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI) |
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
|
6 | Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JC83 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI) |
Negative regulation of response to wounding GO:1903035
Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding.
|
6 | Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JC83 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP) |
Regulation of planar cell polarity pathway involved in axis elongation GO:2000040
Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.
|
6 | Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JC83 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA) |
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
5 | O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS) Q8MIT6 (/ISS) |
Positive regulation of focal adhesion assembly GO:0051894
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
|
5 | O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS) Q8MIT6 (/ISS) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
4 | O75116 (/ISS) O75116 (/ISS) Q28021 (/ISS) Q62868 (/ISS) |
Epithelial cilium movement involved in determination of left/right asymmetry GO:0060287
The movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves.
|
4 | A0A0R4IQJ2 (/IMP) E2CYN3 (/IMP) E7FDG0 (/IMP) F1R417 (/IMP) |
Kupffer's vesicle development GO:0070121
The progression of the Kupffer's vesicle over time from its initial formation until its mature state. The Kupffer's vesicle is a small but distinctive epithelial sac containing fluid, located midventrally posterior to the yolk cell or its extension, and transiently present during most of the segmentation period.
|
4 | A0A0R4IQJ2 (/IMP) E2CYN3 (/IMP) E7FDG0 (/IMP) F1R417 (/IMP) |
Response to transforming growth factor beta GO:0071559
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
4 | P70335 (/IGI) P70336 (/IGI) Q62868 (/IGI) Q63644 (/IGI) |
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Smooth muscle contraction GO:0006939
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
3 | Q62868 (/IMP) Q63644 (/IMP) Q8MIT6 (/IMP) |
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
3 | P70336 (/IMP) Q13464 (/IMP) Q62868 (/IMP) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
3 | O75116 (/IGI) O75116 (/IGI) Q13464 (/IGI) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Negative regulation of myosin-light-chain-phosphatase activity GO:0035509
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
|
3 | O75116 (/IGI) O75116 (/IGI) Q13464 (/IGI) |
Negative regulation of myosin-light-chain-phosphatase activity GO:0035509
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Regulation of keratinocyte differentiation GO:0045616
Any process that modulates the frequency, rate or extent of keratinocyte differentiation.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Regulation of stress fiber assembly GO:0051492
Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
3 | A0A0R4IVY5 (/IMP) O75116 (/IMP) O75116 (/IMP) |
Regulation of focal adhesion assembly GO:0051893
Any process that modulates the frequency, rate or extent of focal adhesion formation, the establishment and maturation of focal adhesions.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Negative regulation of biomineral tissue development GO:0070168
Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Response to transforming growth factor beta GO:0071559
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
3 | O75116 (/IGI) O75116 (/IGI) Q13464 (/IGI) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Regulation of blood vessel diameter GO:0097746
Any process that modulates the diameter of blood vessels.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Positive regulation of amyloid precursor protein catabolic process GO:1902993
Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.
|
3 | O75116 (/IMP) O75116 (/IMP) P70336 (/IMP) |
Regulation of establishment of endothelial barrier GO:1903140
Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.
|
3 | O75116 (/IGI) O75116 (/IGI) Q13464 (/IGI) |
Regulation of establishment of endothelial barrier GO:1903140
Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.
|
3 | O75116 (/IMP) O75116 (/IMP) Q13464 (/IMP) |
Negative regulation of bicellular tight junction assembly GO:1903347
Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly.
|
3 | O75116 (/IGI) O75116 (/IGI) Q13464 (/IGI) |
Positive regulation of connective tissue replacement GO:1905205
Any process that activates or increases the frequency, rate or extent of connective tissue replacement.
|
3 | P70336 (/IMP) Q13464 (/IMP) Q62868 (/IMP) |
Response to angiotensin GO:1990776
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
|
3 | O75116 (/ISS) O75116 (/ISS) Q13464 (/ISS) |
Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
|
3 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) |
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Aortic valve morphogenesis GO:0003180
The process in which the structure of the aortic valve is generated and organized.
|
2 | I3LFH3 (/IGI) M3TYT0 (/IGI) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | O75116 (/IDA) O75116 (/IDA) |
Protein catabolic process in the vacuole GO:0007039
The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases.
|
2 | A0A0R4IHT4 (/IPI) Q90Y37 (/IPI) |
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
2 | A0A0R4IHT4 (/IMP) Q90Y37 (/IMP) |
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | P70335 (/IGI) P70336 (/IGI) |
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
2 | A0A0R4IHT4 (/IPI) Q90Y37 (/IPI) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Cortical actin cytoskeleton organization GO:0030866
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Regulation of nervous system process GO:0031644
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Positive regulation of connective tissue growth factor production GO:0032723
Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Negative regulation of myosin-light-chain-phosphatase activity GO:0035509
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Polar body extrusion after meiotic divisions GO:0040038
The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes.
|
2 | F1MF50 (/IMP) Q8MIT6 (/IMP) |
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
|
2 | A0A0R4IHT4 (/IMP) Q90Y37 (/IMP) |
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | M3TYT0 (/IMP) P70336 (/IMP) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | P70336 (/IMP) Q13464 (/IMP) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Regulation of keratinocyte differentiation GO:0045616
Any process that modulates the frequency, rate or extent of keratinocyte differentiation.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Mesodermal cell differentiation GO:0048333
The process in which a relatively unspecialized cell acquires the specialized features of a mesoderm cell.
|
2 | A0A0R4IHT4 (/IGI) Q90Y37 (/IGI) |
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Centrosome duplication GO:0051298
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Mediolateral intercalation GO:0060031
The interdigitation of cells along the mediolateral axis during gastrulation.
|
2 | A0A0R4IHT4 (/IMP) Q90Y37 (/IMP) |
Planar cell polarity pathway involved in gastrula mediolateral intercalation GO:0060775
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) contributing to the interdigitation of cells along the mediolateral axis during gastrulation.
|
2 | A0A0R4IHT4 (/IMP) Q90Y37 (/IMP) |
MRNA destabilization GO:0061157
Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns.
|
2 | P70335 (/IMP) P70336 (/IMP) |
Negative regulation of biomineral tissue development GO:0070168
Any process that stops, prevents, or reduces the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
|
2 | I3LFH3 (/IGI) M3TYT0 (/IGI) |
Cellular response to testosterone stimulus GO:0071394
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Response to transforming growth factor beta GO:0071559
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Cellular response to transforming growth factor beta stimulus GO:0071560
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transforming growth factor beta stimulus.
|
2 | I3LFH3 (/IGI) M3TYT0 (/IGI) |
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Positive regulation of fibroblast growth factor production GO:0090271
Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Regulation of blood vessel diameter GO:0097746
Any process that modulates the diameter of blood vessels.
|
2 | P70335 (/IMP) P70336 (/IMP) |
Regulation of angiotensin-activated signaling pathway GO:0110061
Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway.
|
2 | P70336 (/IMP) Q13464 (/IMP) |
Regulation of angiotensin-activated signaling pathway GO:0110061
Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Negative regulation of protein localization to lysosome GO:0150033
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
2 | I3LFH3 (/IGI) M3TYT0 (/IGI) |
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Positive regulation of protein localization to early endosome GO:1902966
Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
|
2 | O75116 (/IMP) O75116 (/IMP) |
Positive regulation of amyloid precursor protein catabolic process GO:1902993
Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Regulation of establishment of endothelial barrier GO:1903140
Any process that modulates the frequency, rate or extent of establishment of endothelial barrier.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Negative regulation of bicellular tight junction assembly GO:1903347
Any process that stops, prevents or reduces the frequency, rate or extent of tight junction assembly.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Cellular response to acetylcholine GO:1905145
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Positive regulation of connective tissue replacement GO:1905205
Any process that activates or increases the frequency, rate or extent of connective tissue replacement.
|
2 | P70335 (/ISO) P70336 (/ISO) |
Positive regulation of connective tissue replacement GO:1905205
Any process that activates or increases the frequency, rate or extent of connective tissue replacement.
|
2 | O75116 (/ISS) O75116 (/ISS) |
Response to angiotensin GO:1990776
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.
|
2 | P70335 (/IGI) P70336 (/IGI) |
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | P70336 (/IGI) |
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
1 | P70336 (/ISO) |
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
|
1 | P70336 (/IMP) |
Epicardial cell to mesenchymal cell transition GO:0003347
A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.
|
1 | A0A0R4IVY5 (/IMP) |
Apical constriction GO:0003383
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.
|
1 | P70335 (/IGI) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P70336 (/IMP) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P70336 (/ISO) |
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | Q63644 (/IMP) |
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | P70335 (/ISO) |
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
|
1 | Q13464 (/IDA) |
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
|
1 | P70335 (/ISO) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q13464 (/TAS) |
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
1 | Q13464 (/IGI) |
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
|
1 | Q13464 (/TAS) |
Extrinsic apoptotic signaling pathway via death domain receptors GO:0008625
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
|
1 | P70336 (/IGI) |
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q13464 (/TAS) |
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q13464 (/IGI) |
Positive regulation of autophagy GO:0010508
Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | P70335 (/ISO) |
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
1 | P70336 (/ISO) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P70336 (/IMP) |
Positive regulation of centrosome duplication GO:0010825
Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
|
1 | P70336 (/IMP) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | Q13464 (/IDA) |
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
1 | P70336 (/ISO) |
Membrane to membrane docking GO:0022614
The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere.
|
1 | Q13464 (/IDA) |
Membrane to membrane docking GO:0022614
The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere.
|
1 | P70335 (/ISO) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q28021 (/ISS) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q13464 (/TAS) |
Chromosome condensation GO:0030261
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
|
1 | Q62868 (/TAS) |
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P70336 (/ISO) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | Q13464 (/IGI) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P70335 (/ISO) |
Regulation of nervous system process GO:0031644
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.
|
1 | P70336 (/IMP) |
Bleb assembly GO:0032060
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
|
1 | P70335 (/IMP) |
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | Q13464 (/IDA) |
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | P70335 (/ISO) |
Positive regulation of connective tissue growth factor production GO:0032723
Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.
|
1 | Q62868 (/IMP) |
Positive regulation of connective tissue growth factor production GO:0032723
Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.
|
1 | P70336 (/ISO) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q13464 (/IDA) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P70335 (/ISO) |
Regulation of actin filament-based process GO:0032970
Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.
|
1 | P70335 (/IGI) |
Viral RNA genome replication GO:0039694
The replication of a viral RNA genome.
|
1 | P70336 (/ISO) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | Q13464 (/TAS) |
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
|
1 | P70335 (/ISO) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | P70335 (/IMP) |
Negative regulation of nitric oxide biosynthetic process GO:0045019
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
1 | P70336 (/ISO) |
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
|
1 | Q13464 (/IGI) |
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
|
1 | P70335 (/ISO) |
Dendrite morphogenesis GO:0048813
The process in which the anatomical structures of a dendrite are generated and organized.
|
1 | P70336 (/IGI) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
1 | Q13464 (/IDA) |
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
1 | P70335 (/ISO) |
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
|
1 | Q13464 (/IDA) |
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
|
1 | P70335 (/ISO) |
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
|
1 | Q13464 (/TAS) |
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
|
1 | P70336 (/IMP) |
Centrosome duplication GO:0051298
The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
|
1 | P70336 (/ISO) |
Myoblast migration GO:0051451
The orderly movement of a myoblast from one site to another, often during the development of a multicellular organism. A myoblast is a cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
1 | P70335 (/IMP) |
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | A0A0R4IVY5 (/IMP) |
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | P70336 (/ISO) |
Positive regulation of focal adhesion assembly GO:0051894
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions.
|
1 | P70335 (/IMP) |
Cellular response to testosterone stimulus GO:0071394
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.
|
1 | P70336 (/ISO) |
Positive regulation of fibroblast growth factor production GO:0090271
Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | Q62868 (/IMP) |
Positive regulation of fibroblast growth factor production GO:0090271
Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | P70336 (/ISO) |
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
|
1 | P70336 (/IDA) |
Postsynaptic actin cytoskeleton organization GO:0098974
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton.
|
1 | P70336 (/IMP) |
Assembly of apicomedial cortex actomyosin GO:0106036
A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin.
|
1 | Q9VXE3 (/IDA) |
Assembly of apicomedial cortex actomyosin GO:0106036
A process which results in the assembly or arrangement of constituent parts apicomedial cortex actomyosin.
|
1 | Q9VXE3 (/IMP) |
Regulation of angiotensin-activated signaling pathway GO:0110061
Any process that modulates the frequency, rate or extent of the angiotensin-activated signaling pathway.
|
1 | P70335 (/ISO) |
Neuron projection arborization GO:0140058
The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | Q13464 (/IGI) |
Neuron projection arborization GO:0140058
The process in which the anatomical structures of a neuron projection are generated and organized into branches. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | P70335 (/ISO) |
Negative regulation of protein localization to lysosome GO:0150033
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to lysosome.
|
1 | P70336 (/ISO) |
Regulation of cellular response to hypoxia GO:1900037
Any process that modulates the frequency, rate or extent of cellular response to hypoxia.
|
1 | P70336 (/IMP) |
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
|
1 | Q13464 (/IGI) |
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
|
1 | P70335 (/ISO) |
Regulation of synaptic vesicle endocytosis GO:1900242
Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
|
1 | Q13464 (/IGI) |
Regulation of synaptic vesicle endocytosis GO:1900242
Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis.
|
1 | P70335 (/ISO) |
Regulation of actomyosin contractile ring localization GO:1901648
Any process that modulates the frequency, rate or extent of actomyosin contractile ring localization.
|
1 | Q9VXE3 (/IMP) |
Regulation of amyloid-beta formation GO:1902003
Any process that modulates the frequency, rate or extent of amyloid-beta formation.
|
1 | Q13464 (/TAS) |
Positive regulation of amyloid-beta formation GO:1902004
Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
|
1 | P70336 (/ISO) |
Negative regulation of amyloid-beta formation GO:1902430
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
|
1 | Q13464 (/IMP) |
Negative regulation of amyloid-beta formation GO:1902430
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
|
1 | P70335 (/ISO) |
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process GO:1902961
Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
|
1 | P70336 (/ISO) |
Positive regulation of protein localization to early endosome GO:1902966
Any process that activates or increases the frequency, rate or extent of protein localization to early endosome.
|
1 | P70336 (/ISO) |
Negative regulation of amyloid precursor protein catabolic process GO:1902992
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | Q13464 (/IMP) |
Negative regulation of amyloid precursor protein catabolic process GO:1902992
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | P70335 (/ISO) |
Positive regulation of amyloid precursor protein catabolic process GO:1902993
Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | P70336 (/ISO) |
Negative regulation of adherens junction organization GO:1903392
Any process that stops, prevents or reduces the frequency, rate or extent of adherens junction organization.
|
1 | A0A0R4IVY5 (/IMP) |
Positive regulation of cell maturation GO:1903431
Any process that activates or increases the frequency, rate or extent of cell maturation.
|
1 | Q8MIT6 (/IMP) |
Cellular response to acetylcholine GO:1905145
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetylcholine stimulus.
|
1 | P70336 (/IMP) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell-cell contact zone GO:0044291
Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
|
6 | Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JC83 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | O75116 (/TAS) O75116 (/TAS) Q13464 (/TAS) Q28021 (/TAS) Q9U779 (/TAS) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
4 | O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
4 | O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
4 | O77819 (/ISS) P61584 (/ISS) Q13464 (/ISS) Q63644 (/ISS) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
3 | O75116 (/IDA) O75116 (/IDA) P70336 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | E9PF63 (/IDA) O75116 (/IDA) O75116 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | A0A0R4IHT4 (/IDA) P70335 (/IDA) Q90Y37 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | F1MF50 (/IDA) Q8MIT6 (/IDA) |
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
2 | O75116 (/IDA) O75116 (/IDA) |
Ruffle GO:0001726
Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.
|
1 | P70335 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | Q13464 (/TAS) |
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
|
1 | P70336 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P70336 (/ISO) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
1 | P70335 (/IDA) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q9VXE3 (/IDA) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | P70335 (/IDA) |
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q13464 (/ISS) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | P70335 (/IDA) |
Spindle pole centrosome GO:0031616
A centrosome from which one pole of a mitotic or meiotic spindle is organized.
|
1 | P70336 (/IDA) |
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
|
1 | Q13464 (/TAS) |
Cytoplasmic ribonucleoprotein granule GO:0036464
A ribonucleoprotein granule located in the cytoplasm.
|
1 | P70336 (/ISO) |
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
1 | P70336 (/IDA) |
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
|
1 | P70336 (/IMP) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P70336 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | P70336 (/IMP) |
Apicomedial cortex GO:0106037
The region that lies just beneath the plasma membrane in the middle of the apical edge of a cell.
|
1 | Q9VXE3 (/IDA) |