The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 147:

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microfilament motor activity GO:0000146
Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
2 O74805 (/IDA) O94477 (/IDA)
Actin-dependent ATPase activity GO:0030898
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.
2 O74805 (/IDA) O94477 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 O74805 (/NAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 O74805 (/ISM)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin filament bundle organization GO:0061572
A process that results in the assembly, arrangement of constituent parts, or disassembly of an actin filament bundle.
2 O74805 (/IMP) O94477 (/IMP)
Formin-nucleated actin cable assembly GO:0070649
The aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.
2 O74805 (/IMP) O94477 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 O94477 (/IMP)
Vesicle transport along actin filament GO:0030050
Movement of a vesicle along an actin filament, mediated by motor proteins.
1 O94477 (/IMP)
Actin filament bundle retrograde transport GO:0061573
A process of actin filament bundle distribution that results in the arrangement of actin filament bundles from the periphery toward the interior of the cell.
1 O94477 (/IMP)
Establishment or maintenance of cell polarity regulating cell shape GO:0071963
Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.
1 O94477 (/IMP)
Mitotic actomyosin contractile ring assembly GO:1903475
Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis.
1 O74805 (/IMP)
Actin filament bundle convergence involved in mitotic contractile ring assembly GO:1903478
Any actin filament bundle convergence that is involved in mitotic actomyosin contractile ring assembly.
1 O74805 (/IMP)
Protein localization to actin fusion focus GO:1904601
A process in which a protein is transported to, or maintained in, a location within an actin fusion focus.
1 O74805 (/EXP)
Protein localization to actin fusion focus GO:1904601
A process in which a protein is transported to, or maintained in, a location within an actin fusion focus.
1 O94477 (/IMP)
Protein localization to cell cortex of cell tip GO:1990896
A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip.
1 O94477 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
2 O74805 (/IDA) O94477 (/IDA)
Actin fusion focus GO:1990819
A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location.
2 O74805 (/IDA) O94477 (/IDA)
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis.
1 O74805 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O74805 (/HDA)
Myosin complex GO:0016459
A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.
1 O74805 (/ISM)
Actin cortical patch GO:0030479
An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
1 O94477 (/IDA)
Medial cortex GO:0031097
A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.
1 O94477 (/IDA)
Cell division site GO:0032153
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.
1 O94477 (/HDA)
Cell cortex of cell tip GO:0051285
The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell.
1 O94477 (/IDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 O94477 (/HDA)
Cell tip GO:0051286
The region at the end of the longest axis of a cylindrical or elongated cell.
1 O94477 (/IDA)
Formin-nucleated actin cable GO:0070648
An actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins. In fungal cells, myosin motors transport cargo along actin cables toward sites of polarized cell growth; actin cables may play a similar role in pollen tube growth.
1 O74805 (/IDA)
Cortical dynamic polarity patch GO:0090726
A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation.
1 O94477 (/IDA)
Lateral cell cortex GO:0097575
The region directly beneath the plasma membrane of the lateral portion of the cell.
1 O94477 (/IDA)
Actomyosin contractile ring, proximal layer GO:0120104
The region of the actomyosin ring adjacent to the plasma membrane where membrane bound scaffolds are located.
1 O74805 (/IDA)
Cell cortex of growing cell tip GO:1902716
Any cell cortex that is part of a growing cell tip.
1 O94477 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...