CATH Superfamily 1.20.5.170
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 68: Sodium/potassium-transporting ATPase subunit beta
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
4 | P13638 (/IDA) P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P14415 (/IPI) P14415 (/IPI) P14415 (/IPI) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
3 | P14415 (/IPI) P14415 (/IPI) P14415 (/IPI) |
|
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
|
2 | P14231 (/ISO) P14231 (/ISO) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
|
3 | P14415 (/TAS) P14415 (/TAS) P14415 (/TAS) |
|
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
3 | P14415 (/TAS) P14415 (/TAS) P14415 (/TAS) |
|
Membrane repolarization GO:0086009
The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Cell communication by electrical coupling involved in cardiac conduction GO:0086064
The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.
|
3 | P14415 (/TAS) P14415 (/TAS) P14415 (/TAS) |
|
Positive regulation of potassium ion transmembrane transporter activity GO:1901018
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Positive regulation of potassium ion import across plasma membrane GO:1903288
Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
|
3 | P14415 (/TAS) P14415 (/TAS) P14415 (/TAS) |
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Membrane repolarization GO:0086009
The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Positive regulation of potassium ion transmembrane transporter activity GO:1901018
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Positive regulation of potassium ion import across plasma membrane GO:1903288
Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
|
2 | P14231 (/ISO) P14231 (/ISO) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | P14415 (/TAS) P14415 (/TAS) P14415 (/TAS) |
|
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
3 | P14415 (/IDA) P14415 (/IDA) P14415 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
3 | P13638 (/IDA) P14231 (/IDA) P14231 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P14231 (/IDA) P14231 (/IDA) |
|
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
|
2 | P14231 (/ISO) P14231 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | P14231 (/ISO) P14231 (/ISO) |
