CATH Superfamily 1.20.5.170

FunFam 166: Activating transcription factor-2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Protein homodimerization activity GO:0042803 Interacting selectively and non-covalently with an identical protein to form a homodimer.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Sequence-specific DNA binding GO:0043565 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.	2	Q2PE13 (/IDA) Q56H90 (/IDA)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Mucosal immune response GO:0002385 An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.	2	Q2PE13 (/IMP) Q56H90 (/IMP)
Response to salt stress GO:0009651 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.	2	Q2PE13 (/IMP) Q56H90 (/IMP)
Regulation of triglyceride biosynthetic process GO:0010866 Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.	2	Q2PE13 (/IMP) Q56H90 (/IMP)
Sleep GO:0030431 Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.	2	Q2PE13 (/IMP) Q56H90 (/IMP)
Positive regulation of heterochromatin assembly GO:0031453 Any process that activates or increases the frequency, rate or extent of heterochromatin formation.	2	Q2PE13 (/IMP) Q56H90 (/IMP)
Cellular response to heat GO:0034605 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944 Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Stress-activated MAPK cascade GO:0051403 A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Heterochromatin maintenance GO:0070829 The chromatin organization process that preserves heterochromatin in a stable functional or structural state.	2	Q2PE13 (/IMP) Q56H90 (/IMP)
Cellular response to osmotic stress GO:0071470 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.	2	Q2PE13 (/IDA) Q56H90 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Polytene chromosome chromocenter GO:0005701 A region at which the centric regions of polytene chromosomes are joined together.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Polytene chromosome band GO:0005704 A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band.	2	Q2PE13 (/IDA) Q56H90 (/IDA)
Nuclear pericentric heterochromatin GO:0031618 Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.	2	Q2PE13 (/IDA) Q56H90 (/IDA)

Functional Families

There are 3 GO terms relating to "molecular function"

There are 10 GO terms relating to "biological process"

There are 4 GO terms relating to "cellular component"