The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: RUN and FYVE domain-containing 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
12 Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q7L099 (/IPI) Q8BIJ7 (/IPI)
(2 more)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q96T51 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q8BIJ7 (/ISO)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
1 Q96T51 (/IPI)
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
1 Q8BIJ7 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
11 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
11 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
11 Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
11 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
11 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
9 Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
3 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q9D394 (/ISS)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 Q96T51 (/TAS)
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
1 Q9D394 (/IMP)
Small GTPase mediated signal transduction GO:0007264
Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
1 Q8BIJ7 (/IDA)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8BIJ7 (/IDA)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 Q8BIJ7 (/IDA)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 Q96T51 (/IPI)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 Q8BIJ7 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q9D394 (/ISO)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 Q9D394 (/IDA)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
1 Q9D394 (/IMP)
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
1 Q5FVJ0 (/IDA)
Negative regulation of axonogenesis GO:0050771
Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis.
1 Q9D394 (/ISO)
Positive regulation of axonogenesis GO:0050772
Any process that activates or increases the frequency, rate or extent of axonogenesis.
1 Q9D394 (/IDA)
Positive regulation of intracellular protein transport GO:0090316
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.
1 Q9D394 (/IDA)
Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
1 Q9D394 (/IDA)

There are 36 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
12 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 H0YAC8 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA)
(1 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
11 Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
11 Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
11 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
11 Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
11 Q5R4V2 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS) Q7L099 (/ISS)
(1 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q8BIJ7 (/IDA)
Invadopodium GO:0071437
A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate.
9 Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA) Q7L099 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q9D394 (/ISS)
Invadopodium GO:0071437
A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate.
3 Q5FVJ0 (/ISS) Q5R4V2 (/ISS) Q9D394 (/ISS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
2 H0YAC8 (/IDA) Q96T51 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q5FVJ0 (/IDA) Q9D394 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 Q5FVJ0 (/IDA) Q9D394 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
2 Q5FVJ0 (/IDA) Q9D394 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
2 H0YAC8 (/IDA) Q96T51 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q96T51 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q8BIJ7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9D394 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q96T51 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q8BIJ7 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9D394 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q96T51 (/TAS)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
1 Q8BIJ7 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q5FVJ0 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 Q9D394 (/ISO)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q5FVJ0 (/IDA)
Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
1 Q9D394 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q9D394 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q9D394 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q9D394 (/ISO)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 Q96T51 (/TAS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9D394 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 Q9D394 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q8BIJ7 (/ISO)
Invadopodium GO:0071437
A cell projection that emerges from the ECM-facing surface of a cell, is enriched in actin and associated cytoskeletal proteins, and displays localized proteolytic activity toward the substrate.
1 Q9D394 (/ISO)
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