The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Transcription factor MafG, putative

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
47 O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI) O15525 (/IPI)
(37 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
29 A0A0R4IVU1 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA)
(19 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM) O15525 (/ISM)
(12 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
22 O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS)
(12 more)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
21 O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA)
(11 more)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
21 O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA)
(11 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
21 O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI) O54790 (/IPI)
(11 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
21 O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS) O15525 (/NAS)
(11 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
21 O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS) O54790 (/TAS)
(11 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
11 A0A0B4LH09 (/IPI) A0A0R4IVU1 (/IPI) Q4QPP9 (/IPI) Q4QPP9 (/IPI) Q4QPP9 (/IPI) Q4QPP9 (/IPI) Q4V999 (/IPI) Q6I6N0 (/IPI) Q6I6N2 (/IPI) Q6NW89 (/IPI)
(1 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
6 O54791 (/ISO) O54791 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 A0A0R4IVU1 (/IDA) Q4V999 (/IDA) Q6I6N0 (/IDA) Q6IRI7 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
4 Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
Transcription cofactor binding GO:0001221
Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
4 Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
4 Q61827 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q61827 (/IDA)
RING-like zinc finger domain binding GO:0071535
Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.
4 Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 O60675 (/ISA) O60675 (/ISA) Q9ULX9 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 M9PG80 (/ISS) Q7JS61 (/ISS) Q9VIW0 (/ISS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 O60675 (/IDA) O60675 (/IDA) Q9ULX9 (/IDA)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2 O60675 (/IC) O60675 (/IC)
Transcription cofactor binding GO:0001221
Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
1 Q6IRI7 (/IPI)
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q9ULX9 (/IC)
RING-like zinc finger domain binding GO:0071535
Interacting selectively and non-covalently with a RING-like zinc finger domain domain of a protein. The RING-like domain is a zinc finger domain that is related to the C3HC4 RING finger domain.
1 Q6IRI7 (/IPI)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
27 A0A0B4LH09 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA) O54790 (/IDA)
(17 more)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
23 O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI)
(13 more)
Regulation of epidermal cell differentiation GO:0045604
Any process that modulates the frequency, rate or extent of epidermal cell differentiation.
23 O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI)
(13 more)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
22 O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS)
(12 more)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
21 O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI) O54790 (/IGI)
(11 more)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
21 O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP)
(11 more)
Regulation of cellular pH GO:0030641
Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.
21 O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO) O54790 (/ISO)
(11 more)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
21 O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP) O54790 (/IMP)
(11 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
7 A0A0R4IVU1 (/IDA) Q4V999 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q6I6N0 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
6 A0A0R4IVU1 (/IGI) Q4V999 (/IGI) Q6I6N0 (/IGI) Q6I6N2 (/IGI) Q6NW89 (/IGI) Q7T3H0 (/IGI)
Head development GO:0060322
The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
5 A0A0B4LH09 (/IMP) Q4QPP9 (/IMP) Q4QPP9 (/IMP) Q4QPP9 (/IMP) Q4QPP9 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
4 Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
3 A0A0R4IVU1 (/IGI) Q4V999 (/IGI) Q6I6N0 (/IGI)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
3 M9PG80 (/IMP) Q7JS61 (/IMP) Q9VIW0 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
3 M9PG80 (/HMP) Q7JS61 (/HMP) Q9VIW0 (/HMP)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
3 M9PG80 (/HMP) Q7JS61 (/HMP) Q9VIW0 (/HMP)
Gene expression GO:0010467
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 M9PG80 (/IMP) Q7JS61 (/IMP) Q9VIW0 (/IMP)
Gonad morphogenesis GO:0035262
The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.
3 M9PG80 (/IMP) Q7JS61 (/IMP) Q9VIW0 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
3 M9PG80 (/IMP) Q7JS61 (/IMP) Q9VIW0 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 O60675 (/IDA) O60675 (/IDA)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
2 O54791 (/IMP) O54791 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O54791 (/ISO) O54791 (/ISO)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 M9PG80 (/IMP)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
1 Q9ULX9 (/TAS)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
1 M9PG80 (/IMP)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q6IRI7 (/IDA)
Parturition GO:0007567
The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.
1 Q9ULX9 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 M9PG80 (/IMP)
Regulation of cellular pH GO:0030641
Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.
1 Q76MX4 (/IDA)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
28 O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS) O15525 (/TAS)
(18 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 B0QY70 (/IDA) M9PG80 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q61827 (/IDA) Q7JS61 (/IDA) Q9ULX9 (/IDA) Q9VIW0 (/IDA)
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
6 A0A0R4IVU1 (/IDA) Q4V999 (/IDA) Q6I6N0 (/IDA) Q6I6N2 (/IDA) Q6NW89 (/IDA) Q7T3H0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A0A024R804 (/IDA) A0A024R804 (/IDA) O60675 (/IDA) O60675 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO) Q61827 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O54791 (/ISO) O54791 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 B0QY70 (/IDA) Q9ULX9 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 O54791 (/ISO) O54791 (/ISO)
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