The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: SET isoform 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 Q01105 (/IPI) Q01105 (/IPI) Q01105 (/IPI) Q01105 (/IPI) Q01105 (/IPI) Q63945 (/IPI) Q63945 (/IPI)
Protein phosphatase inhibitor activity GO:0004864
Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Protein phosphatase regulator activity GO:0019888
Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
2 Q9CA59 (/IDA) Q9CA59 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 P0DME0 (/IDA)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Nucleosome assembly GO:0006334
The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Nucleosome disassembly GO:0006337
The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Negative regulation of histone acetylation GO:0035067
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
5 Q01105 (/IGI) Q01105 (/IGI) Q01105 (/IGI) Q01105 (/IGI) Q01105 (/IGI)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
5 Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA)
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
4 Q8LC68 (/IGI) Q8LC68 (/IGI) Q9CA59 (/IGI) Q9CA59 (/IGI)
Somatic cell DNA recombination GO:0016444
Recombination occurring within or between DNA molecules in somatic cells.
4 Q8LC68 (/IMP) Q8LC68 (/IMP) Q9CA59 (/IMP) Q9CA59 (/IMP)
Neuromast development GO:0048884
The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals.
4 A0A2R8QJ70 (/IMP) F1R3I6 (/IMP) Q6NYZ1 (/IMP) Q6TGU0 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 Q9CA59 (/IEP) Q9CA59 (/IEP)
Endothelial cell differentiation GO:0045446
The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
1 P0DME0 (/IDA)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P0DME0 (/IDA)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 P0DME0 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q8LC68 (/IDA) Q8LC68 (/IDA) Q9CA59 (/IDA) Q9CA59 (/IDA)
(2 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
12 A0A087X027 (/IDA) P0DME0 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q5VXV3 (/IDA) Q5VXV3 (/IDA) Q5VXV3 (/IDA)
(2 more)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
12 A0A087X027 (/IDA) P0DME0 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q5VXV3 (/IDA) Q5VXV3 (/IDA) Q5VXV3 (/IDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
10 P0DME0 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q8LC68 (/IDA) Q8LC68 (/IDA) Q9CA59 (/IDA) Q9CA59 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q01105 (/HDA) Q01105 (/HDA) Q01105 (/HDA) Q01105 (/HDA) Q01105 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS) Q01105 (/TAS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
5 Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
5 Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA) Q01105 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q63945 (/ISS) Q63945 (/ISS) Q9EQU5 (/ISS) Q9EQU5 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 Q63945 (/ISS) Q63945 (/ISS) Q9EQU5 (/ISS) Q9EQU5 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 Q63945 (/ISS) Q63945 (/ISS) Q9EQU5 (/ISS) Q9EQU5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Lipid droplet GO:0005811
An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9CA59 (/IDA) Q9CA59 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q9EQU5 (/ISO) Q9EQU5 (/ISO)
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