The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 45: Syntaxin 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P70452 (/IPI) Q08850 (/IPI) Q12846 (/IPI) Q12846 (/IPI) Q12846 (/IPI) Q12846 (/IPI) Q3SWZ3 (/IPI) Q3SWZ3 (/IPI)
Sphingomyelin phosphodiesterase activator activity GO:0016230
Increases the activity of the enzyme sphingomyelin phosphodiesterase.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
2 P70452 (/IPI) Q08850 (/IPI)
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
1 P70452 (/ISO)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
1 Q08850 (/IDA)
SNAP receptor activity GO:0005484
Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion.
1 P70452 (/ISO)
Sphingomyelin phosphodiesterase activator activity GO:0016230
Increases the activity of the enzyme sphingomyelin phosphodiesterase.
1 P70452 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q08850 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 P70452 (/ISO)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
1 Q08850 (/IPI)
Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
1 P70452 (/ISO)

There are 50 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Post-Golgi vesicle-mediated transport GO:0006892
The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles.
4 Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Response to hydroperoxide GO:0033194
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Positive regulation of eosinophil degranulation GO:0043311
Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Organelle fusion GO:0048284
The creation of a single organelle from two or more organelles.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041
Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668
The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles.
4 Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P70452 (/ISO)
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
1 P70452 (/TAS)
Synaptic vesicle docking GO:0016081
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
1 Q08850 (/IDA)
Synaptic vesicle docking GO:0016081
The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process.
1 P70452 (/ISO)
Regulation of exocytosis GO:0017157
Any process that modulates the frequency, rate or extent of exocytosis.
1 P70452 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P70452 (/ISO)
Response to hydroperoxide GO:0033194
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
1 P70452 (/ISO)
SNARE complex assembly GO:0035493
The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
1 P70452 (/IDA)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 P70452 (/ISO)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
1 P70452 (/ISO)
Positive regulation of eosinophil degranulation GO:0043311
Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.
1 P70452 (/ISO)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 P70452 (/ISO)
Intracellular transport GO:0046907
The directed movement of substances within a cell.
1 Q08850 (/NAS)
Organelle fusion GO:0048284
The creation of a single organelle from two or more organelles.
1 P70452 (/ISO)
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
1 P70452 (/ISO)
Positive regulation of immunoglobulin secretion GO:0051024
Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell.
1 P70452 (/ISO)
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
1 P70452 (/ISO)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 Q08850 (/IDA)
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
1 P70452 (/ISO)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
1 Q08850 (/IDA)
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
1 P70452 (/ISO)
Cellular response to interferon-gamma GO:0071346
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon gamma is the only member of the type II interferon found so far.
1 P70452 (/IDA)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0098967
The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
1 Q08850 (/IDA)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0098967
The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
1 Q08850 (/IMP)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0098967
The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion.
1 P70452 (/ISO)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
1 Q08850 (/IDA)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
1 Q08850 (/IMP)
Vesicle-mediated transport in synapse GO:0099003
Any vesicle-mediated transport that occurs in a synapse
1 P70452 (/ISO)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041
Any process that modulates the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.
1 P70452 (/ISO)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 P70452 (/ISO)
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
1 P70452 (/ISO)

There are 48 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P70452 (/IDA) Q08850 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
6 P70452 (/IDA) Q08850 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
6 P70452 (/IDA) Q08850 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 P70452 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
5 P70452 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
5 Q08850 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
5 Q08850 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
4 Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
4 Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS) Q12846 (/TAS)
Somatodendritic compartment GO:0036477
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q12846 (/HDA) Q12846 (/HDA) Q12846 (/HDA) Q12846 (/HDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
4 Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA) Q12846 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
4 Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP) Q12846 (/IMP)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
3 P70452 (/ISS) Q3SWZ3 (/ISS) Q3SWZ3 (/ISS)
Caveola GO:0005901
A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.
2 Q3SWZ3 (/IDA) Q3SWZ3 (/IDA)
Storage vacuole GO:0000322
A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.
1 P70452 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P70452 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P70452 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 P70452 (/ISO)
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
1 P70452 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P70452 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P70452 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P70452 (/ISO)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P70452 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q08850 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 P70452 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 P70452 (/ISO)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
1 P70452 (/ISO)
Myelin sheath adaxonal region GO:0035749
The region of the myelin sheath nearest to the axon.
1 P70452 (/IDA)
Somatodendritic compartment GO:0036477
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
1 P70452 (/ISO)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 Q08850 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 P70452 (/ISO)
Specific granule GO:0042581
Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 P70452 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P70452 (/ISO)
Lateral loop GO:0043219
Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.
1 P70452 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P70452 (/ISO)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 P70452 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P70452 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 P70452 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P70452 (/ISO)
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