The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: Vesicle-trafficking protein SEC22b

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
28 O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI) O08547 (/IPI)
(18 more)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
27 Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI) Q4KM74 (/IPI)
(17 more)
Syntaxin binding GO:0019905
Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.
27 O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO)
(17 more)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888
The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
28 O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS) O08547 (/TAS)
(18 more)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
27 O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA)
(17 more)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
27 O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO)
(17 more)
Negative regulation of autophagosome assembly GO:1902902
Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.
27 O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO)
(17 more)
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479
The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.
1 O75396 (/TAS)
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006890
The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
1 O75396 (/TAS)
Positive regulation of protein catabolic process GO:0045732
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 O75396 (/IMP)
COPII vesicle coating GO:0048208
The addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.
1 O75396 (/TAS)
Negative regulation of autophagosome assembly GO:1902902
Any process that stops, prevents or reduces the frequency, rate or extent of autophagosome assembly.
1 O75396 (/IMP)
Vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane GO:1990668
The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles.
1 O75396 (/TAS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
27 O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA)
(17 more)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
27 O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA) O08547 (/IDA)
(17 more)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
27 O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO)
(17 more)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
27 Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP) Q4KM74 (/EXP)
(17 more)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
27 Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA) Q4KM74 (/IDA)
(17 more)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
27 O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO)
(17 more)
ER to Golgi transport vesicle membrane GO:0012507
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
27 O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO) O08547 (/ISO)
(17 more)
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
1 O75396 (/TAS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 O75396 (/TAS)
Endoplasmic reticulum-Golgi intermediate compartment GO:0005793
A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
1 O75396 (/IDA)
ER to Golgi transport vesicle membrane GO:0012507
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
1 O75396 (/IDA)
ER to Golgi transport vesicle membrane GO:0012507
The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi.
1 O75396 (/TAS)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 O75396 (/TAS)
Phagocytic vesicle membrane GO:0030670
The lipid bilayer surrounding a phagocytic vesicle.
1 O75396 (/TAS)
Endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
1 O75396 (/TAS)
Exocytic vesicle GO:0070382
A transport vesicle that mediates transport from an intracellular compartment to the plasma membrane, and fuses with the plasma membrane to release various cargo molecules, such as proteins or hormones, by exocytosis.
1 E2R8Y3 (/IDA)
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