The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: BRICK1, SCAR/WAVE actin-nucleating complex subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
30 Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI) Q8MLQ0 (/IPI)
(20 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
20 Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA)
(10 more)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
20 Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI) Q8WUW1 (/IPI)
(10 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
30 Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP)
(20 more)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
20 Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA)
(10 more)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
20 Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP) Q8WUW1 (/IMP)
(10 more)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
20 Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS)
(10 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
20 Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS)
(10 more)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
20 Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA)
(10 more)
Positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601
Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation.
20 Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA) Q8WUW1 (/IDA)
(10 more)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
10 Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP)
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
10 Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP)
Central nervous system morphogenesis GO:0021551
The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
10 Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP)
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
10 Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA)
Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
10 Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP) Q8MLQ0 (/IMP)
In utero embryonic development GO:0001701
The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.
4 Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
4 Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP)
Positive regulation of lamellipodium assembly GO:0010592
Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
4 Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP)
Positive regulation of protein complex assembly GO:0031334
Any process that activates or increases the frequency, rate or extent of protein complex assembly.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
4 Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP) Q91VR8 (/IMP)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)
Positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601
Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
SCAR complex GO:0031209
A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
30 Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA) Q8MLQ0 (/IDA)
(20 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
24 D3ZUP5 (/ISS) D3ZUP5 (/ISS) D3ZUP5 (/ISS) D3ZUP5 (/ISS) Q8WUW1 (/ISS) Q8WUW1 (/ISS) Q8WUW1 (/ISS) Q8WUW1 (/ISS) Q8WUW1 (/ISS) Q8WUW1 (/ISS)
(14 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
20 Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS) Q8WUW1 (/TAS)
(10 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
20 Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA) Q8WUW1 (/HDA)
(10 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
4 Q91VR8 (/IDA) Q91VR8 (/IDA) Q91VR8 (/IDA) Q91VR8 (/IDA)
SCAR complex GO:0031209
A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.
4 Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO) Q91VR8 (/ISO)
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