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CATH Superfamily 1.20.245.10

Lipoxygenase-1; Domain 5

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Lipoxygenase-1; Domain 5
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Arachidonate 5-lipoxygenase a

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Arachidonate 12-lipoxygenase. [EC: 1.13.11.31]
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate.
  • The product is rapidly reduced to the corresponding 12S-hydroxy compound.
 24 A0A2J8SPJ7 A0A2J8SPJ7 A2CF85 A2CF85 A2CF88 A2CF88 D3ZQF9 F1LQ70 P12530 P16050
(14 more...)
Arachidonate 15-lipoxygenase. [EC: 1.13.11.33]
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
  • The product is rapidly converted to the corresponding 15S-hydroxy compound.
 15 A0A2J8SPJ7 A0A2J8SPJ7 A2CF88 A2CF88 O15296 P12530 P16050 P16469 P27479 P39654
(5 more...)
Arachidonate 5-lipoxygenase. [EC: 1.13.11.34]
Arachidonate + O(2) = leukotriene A(4) + H(2)O.
    		 7 A0A1U7Q298 A0A1U7Q298 P09917 P12527 P48999 P51399 P51399
    Hydroperoxy icosatetraenoate isomerase. [EC: 5.4.4.7]
    A hydroperoxy icosatetraenoate = a hydroxy epoxy icosatrienoate.
    • The enzyme from mammals accepts a range of hydroperoxy icosatetraenoates producing one or several different hydroxy epoxy icosatrienoates.
    • The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy- 11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8- hydroxy-11,12-epoxyicosa-5,9,14-trienoate.
    • The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate.
    • The enzymes also have the activity of EC 4.2.1.152.
    		 3 D3ZKX9 Q9BYJ1 Q9WV07
    Hydroperoxy icosatetraenoate dehydratase. [EC: 4.2.1.152]
    A hydroperoxy icosatetraenoate = an oxoicosatetraenoate + H(2)O.
    • The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE).
    • The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency.
    • The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE).
    • The enzymes also catalyze the reaction of EC 5.4.4.7.
    		 3 D3ZKX9 Q9BYJ1 Q9WV07