The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Sodium/glucose cotransporter
".
FunFam 7: Sodium-coupled monocarboxylate transporter 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Lactate transmembrane transporter activity GO:0015129
Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.
|
3 | Q49B93 (/IDA) Q49B93 (/IDA) Q8BYF6 (/IDA) |
|
Sodium:iodide symporter activity GO:0008507
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).
|
2 | Q63008 (/IDA) Q99PN0 (/IDA) |
|
Secondary active monocarboxylate transmembrane transporter activity GO:0015355
Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.
|
2 | Q3ZMH1 (/IDA) Q7T384 (/IDA) |
|
Organic acid:sodium symporter activity GO:0005343
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).
|
1 | Q8BYF6 (/IDA) |
|
Organic acid:sodium symporter activity GO:0005343
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in).
|
1 | Q1EHB4 (/TAS) |
|
Monocarboxylic acid transmembrane transporter activity GO:0008028
Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.
|
1 | Q8N695 (/TAS) |
|
Sodium:iodide symporter activity GO:0008507
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).
|
1 | Q99PN0 (/ISO) |
|
Sodium:iodide symporter activity GO:0008507
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).
|
1 | Q92911 (/TAS) |
|
Iodide transmembrane transporter activity GO:0015111
Enables the transfer of iodide ions from one side of a membrane to the other.
|
1 | Q92911 (/IMP) |
|
Iodide transmembrane transporter activity GO:0015111
Enables the transfer of iodide ions from one side of a membrane to the other.
|
1 | Q99PN0 (/ISO) |
|
Iodide transmembrane transporter activity GO:0015111
Enables the transfer of iodide ions from one side of a membrane to the other.
|
1 | Q92911 (/TAS) |
|
Symporter activity GO:0015293
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
|
1 | Q99PN0 (/IDA) |
|
Propionate transmembrane transporter activity GO:0015552
Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH.
|
1 | Q8BYF6 (/IDA) |
|
Short-chain fatty acid transmembrane transporter activity GO:0015636
Enables the transfer of short-chain fatty acids from one side of a membrane to the other. Short-chain fatty acids are fatty acids with a chain length of less than C6.
|
1 | Q8BYF6 (/IDA) |
|
Passive transmembrane transporter activity GO:0022803
Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.
|
1 | Q8N695 (/TAS) |
|
Monocarboxylate:sodium symporter activity GO:0140161
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in).
|
1 | Q8BYF6 (/IDA) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | Q1EHB4 (/TAS) Q8N695 (/TAS) Q92911 (/TAS) |
|
Thyroid hormone generation GO:0006590
The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
|
2 | Q63008 (/TAS) Q92911 (/TAS) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q63008 (/IDA) |
|
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q99PN0 (/ISO) |
|
Iodide transport GO:0015705
The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q63008 (/IDA) |
|
Iodide transport GO:0015705
The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q92911 (/IMP) |
|
Iodide transport GO:0015705
The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q99PN0 (/ISO) |
|
Monocarboxylic acid transport GO:0015718
The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q8BYF6 (/IDA) |
|
Propanoate transport GO:0015730
The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q8BYF6 (/IDA) |
|
Short-chain fatty acid import GO:0015913
The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6.
|
1 | Q8BYF6 (/IDA) |
|
NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.
|
1 | Q8N695 (/TAS) |
|
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
1 | Q92911 (/IEP) |
|
Cellular response to gonadotropin stimulus GO:0071371
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin stimulus.
|
1 | Q92911 (/IEP) |
There are 10 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q1EHB4 (/TAS) Q8N695 (/TAS) Q92911 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
3 | Q1EHB4 (/HDA) Q8N695 (/HDA) Q92911 (/HDA) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q63008 (/TAS) Q92911 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q92911 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q99PN0 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q63008 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q99PN0 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q8BYF6 (/TAS) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q8BYF6 (/ISO) |
|
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
|
1 | Q92911 (/HDA) |