The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Sodium/glucose cotransporter
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Sodium/proline symporter

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proline:sodium symporter activity GO:0005298
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).
28 A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS)
(18 more)
Proline:sodium symporter activity GO:0005298
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in).
8 P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA)
L-proline transmembrane transporter activity GO:0015193
Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid.
7 Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Proline transport GO:0015824
The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
28 A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS) A0A1Q4M2X8 (/ISS)
(18 more)
Proline transport GO:0015824
The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA)
Proline transport GO:0015824
The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP)
Short-chain fatty acid transport GO:0015912
The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6.
8 P07117 (/IEP) P07117 (/IEP) P07117 (/IEP) P07117 (/IEP) P07117 (/IEP) P07117 (/IEP) P07117 (/IEP) P07117 (/IEP)
Short-chain fatty acid transport GO:0015912
The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6.
8 P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP) P07117 (/IMP)
Proline catabolic process to glutamate GO:0010133
The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate.
7 Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP)
L-proline import across plasma membrane GO:1904271
The directed movement of L-proline from outside of a cell, across the plasma membrane and into the cytosol.
7 Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP) Q9I5F5 (/IMP)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
2 Q79VH1 (/EXP) Q79VH1 (/EXP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
8 P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA) P07117 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 P07117 (/RCA) P07117 (/RCA) P07117 (/RCA) P07117 (/RCA) P07117 (/RCA) P07117 (/RCA) P07117 (/RCA) P07117 (/RCA)