The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Multidrug resistance protein D
".
FunFam 8: Multidrug transporter MdfA
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
|
58 |
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
(48 more) |
|
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
|
58 |
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
(48 more) |
|
Potassium:proton antiporter activity GO:0015386
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
|
58 |
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
(48 more) |
|
Potassium:proton antiporter activity GO:0015386
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in).
|
58 |
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
(48 more) |
|
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
|
58 |
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
(48 more) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
|
58 |
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
(48 more) |
|
Regulation of cellular pH GO:0030641
Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.
|
58 |
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
(48 more) |
|
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
58 |
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
P0AEY8 (/IMP)
(48 more) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
58 |
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
(48 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
58 |
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
P0AEY8 (/IDA)
(48 more) |