The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Multidrug efflux transporter AcrB transmembrane domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8: NPC intracellular cholesterol transporter 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 14 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O15118 (/IPI) O35604 (/IPI) Q12200 (/IPI) Q12200 (/IPI) Q12200 (/IPI) Q12200 (/IPI) Q6T3U4 (/IPI) Q9UHC9 (/IPI)
Molecular function regulator GO:0098772
A molecular function that modulates the activity of a gene product or complex. Examples include enzyme regulators and channel regulators.
4 Q12200 (/IMP) Q12200 (/IMP) Q12200 (/IMP) Q12200 (/IMP)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
2 O35604 (/ISS) P56941 (/ISS)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 O15118 (/TAS)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 Q6T3U3 (/IDA)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
1 Q6T3U4 (/ISO)
Sterol transporter activity GO:0015248
Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 O15118 (/TAS)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 O15118 (/IDA)
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 O35604 (/ISO)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q9UHC9 (/IPI)
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
1 Q6T3U4 (/ISO)
Myosin V binding GO:0031489
Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.
1 Q9UHC9 (/IPI)
Myosin V binding GO:0031489
Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.
1 Q6T3U4 (/ISO)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 O15118 (/TAS)

There are 65 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
12 O15118 (/ISS) O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q7TMD4 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS)
(2 more)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
11 O15118 (/ISS) O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS) Q9N0Q0 (/ISS)
(1 more)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
11 O15118 (/ISS) O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS) Q9N0Q0 (/ISS)
(1 more)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
8 A0A0R4IZV0 (/IMP) A0A2R8Q2J0 (/IMP) F1QNG7 (/IMP) F6N6I8 (/IMP) O15118 (/IMP) O35604 (/IMP) Q6T3U4 (/IMP) Q7TMD4 (/IMP)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
5 A0A0R4IZV0 (/IMP) A0A2R8Q2J0 (/IMP) F1QNG7 (/IMP) F6N6I8 (/IMP) Q9UHC9 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
4 A0A0R4IZV0 (/IDA) A0A2R8Q2J0 (/IDA) F1QNG7 (/IDA) F6N6I8 (/IDA)
Sphingolipid metabolic process GO:0006665
The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
4 Q12200 (/IMP) Q12200 (/IMP) Q12200 (/IMP) Q12200 (/IMP)
Lipid transport GO:0006869
The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
4 A0A0R4IZV0 (/ISS) A0A2R8Q2J0 (/ISS) F1QNG7 (/ISS) F6N6I8 (/ISS)
Sperm individualization GO:0007291
The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.
4 Q7YU59 (/IMP) Q9U5W1 (/IMP) Q9VL24 (/IMP) X2J9B0 (/IMP)
Molting cycle, chitin-based cuticle GO:0007591
The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster.
4 Q7YU59 (/IMP) Q9U5W1 (/IMP) Q9VL24 (/IMP) X2J9B0 (/IMP)
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
4 Q7YU59 (/IMP) Q9U5W1 (/IMP) Q9VL24 (/IMP) X2J9B0 (/IMP)
Regulation of cholesterol transport GO:0032374
Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 Q7YU59 (/IDA) Q9U5W1 (/IDA) Q9VL24 (/IDA) X2J9B0 (/IDA)
Megakaryocyte development GO:0035855
The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
4 A0A0R4IZV0 (/IMP) A0A2R8Q2J0 (/IMP) F1QNG7 (/IMP) F6N6I8 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
4 A0A0R4IZV0 (/IMP) A0A2R8Q2J0 (/IMP) F1QNG7 (/IMP) F6N6I8 (/IMP)
Ecdysteroid biosynthetic process GO:0045456
The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.
4 Q7YU59 (/IMP) Q9U5W1 (/IMP) Q9VL24 (/IMP) X2J9B0 (/IMP)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
4 A0A0R4IZV0 (/IMP) A0A2R8Q2J0 (/IMP) F1QNG7 (/IMP) F6N6I8 (/IMP)
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
2 O15118 (/IDA) O35604 (/IDA)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O35604 (/ISO) Q6T3U4 (/ISO)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O35604 (/ISS) P56941 (/ISS)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
2 O35604 (/ISS) P56941 (/ISS)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
2 O15118 (/IMP) O35604 (/IMP)
Regulation of sphingolipid biosynthetic process GO:0090153
Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
2 F4I9G5 (/IGI) F4JTN1 (/IGI)
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
1 O35604 (/ISO)
Protein glycosylation GO:0006486
A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.
1 P56941 (/ISS)
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 Q9UHC9 (/IMP)
Cholesterol biosynthetic process GO:0006695
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 Q6T3U4 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 O35604 (/IMP)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
1 O15118 (/IGI)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
1 O35604 (/ISO)
Lysosomal transport GO:0007041
The directed movement of substances into, out of or within a lysosome.
1 Q7TMD4 (/IMP)
Adult walking behavior GO:0007628
The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
1 O35604 (/IGI)
Bile acid metabolic process GO:0008206
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
1 Q7TMD4 (/IMP)
Pollen development GO:0009555
The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.
1 F4I9G5 (/IGI)
Negative regulation of macroautophagy GO:0016242
Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
1 O35604 (/IGI)
Negative regulation of macroautophagy GO:0016242
Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
1 O35604 (/IMP)
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
1 Q9UHC9 (/IMP)
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
1 Q6T3U4 (/ISO)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 O15118 (/IDA)
Membrane raft organization GO:0031579
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.
1 O15118 (/IMP)
Membrane raft organization GO:0031579
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.
1 O35604 (/ISO)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
1 O15118 (/IMP)
Intracellular cholesterol transport GO:0032367
The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.
1 O35604 (/ISO)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 O15118 (/IDA)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 O35604 (/IMP)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 O35604 (/ISO)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
1 O15118 (/TAS)
Lipoprotein metabolic process GO:0042157
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 Q9UHC9 (/IMP)
Lipoprotein metabolic process GO:0042157
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
1 Q6T3U4 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 O35604 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q6T3U3 (/IEP)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 O15118 (/IDA)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 O35604 (/ISO)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 G3V7K5 (/IDA)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 O35604 (/ISO)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
1 O35604 (/ISO)
Pollen tube development GO:0048868
The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure.
1 F4JTN1 (/IGI)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 G3V7K5 (/IMP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 O35604 (/ISO)
Cellular response to steroid hormone stimulus GO:0071383
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
1 O35604 (/IDA)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
1 O35604 (/IDA)
Cellular response to sterol depletion GO:0071501
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q9UHC9 (/IDA)
Cellular response to sterol depletion GO:0071501
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q6T3U4 (/ISO)
Establishment of protein localization to membrane GO:0090150
The directed movement of a protein to a specific location in a membrane.
1 O15118 (/IDA)
Establishment of protein localization to membrane GO:0090150
The directed movement of a protein to a specific location in a membrane.
1 O35604 (/ISO)
Intestinal lipid absorption GO:0098856
Any process in which lipids are taken up from the contents of the intestine.
1 Q9UHC9 (/TAS)

There are 42 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
11 O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q7TMD4 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS) Q9N0Q0 (/ISS)
(1 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
11 O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q7TMD4 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS) Q9N0Q0 (/ISS)
(1 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
11 O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q7TMD4 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS) Q9N0Q0 (/ISS)
(1 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
11 O35604 (/ISS) P56941 (/ISS) Q59GR1 (/ISS) Q7TMD4 (/ISS) Q8MI49 (/ISS) Q8MKD8 (/ISS) Q9GK52 (/ISS) Q9GLC9 (/ISS) Q9JLG3 (/ISS) Q9N0Q0 (/ISS)
(1 more)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
4 Q12200 (/HDA) Q12200 (/HDA) Q12200 (/HDA) Q12200 (/HDA)
Fungal-type vacuole membrane GO:0000329
The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
4 Q12200 (/IDA) Q12200 (/IDA) Q12200 (/IDA) Q12200 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
4 Q12200 (/HDA) Q12200 (/HDA) Q12200 (/HDA) Q12200 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
3 O35604 (/IDA) Q5BBG1 (/IDA) Q5BBG1 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
3 B4DIP7 (/HDA) O15118 (/HDA) Q59GR1 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 O15118 (/ISS) P56941 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
2 O15118 (/IDA) O35604 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 O15118 (/ISS) P56941 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 F4I9G5 (/IDA) O35604 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 A0MJA4 (/TAS) Q9UHC9 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 F4JTN1 (/IDA) O35604 (/IDA)
Integral component of lysosomal membrane GO:1905103
The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 O35604 (/ISS) P56941 (/ISS)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 O35604 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O35604 (/IDA)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
1 O15118 (/TAS)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 O15118 (/TAS)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 O35604 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 F4JTN1 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
1 F4JTN1 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O15118 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 O35604 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 O35604 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O15118 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35604 (/ISO)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 F4I9G5 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O15118 (/HDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O15118 (/TAS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q6T3U3 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q6T3U4 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 O35604 (/IDA)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 Q9UHC9 (/IDA)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 Q6T3U4 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 O35604 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 O15118 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 O35604 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O15118 (/HDA)
Integral component of lysosomal membrane GO:1905103
The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O15118 (/IDA)
Integral component of lysosomal membrane GO:1905103
The component of the lysosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 O35604 (/ISO)