The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Multidrug efflux transporter AcrB transmembrane domain
".
FunFam 27: Blast:Protein patched
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P18502 (/IPI) |
|
Hedgehog receptor activity GO:0008158
Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.
|
1 | P18502 (/IMP) |
|
Lipoprotein particle receptor activity GO:0030228
Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
|
1 | P18502 (/IDA) |
|
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
|
1 | P18502 (/IDA) |
|
Hedgehog family protein binding GO:0097108
Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development.
|
1 | P18502 (/IDA) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Bolwig's organ morphogenesis GO:0001746
The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.
|
1 | P18502 (/IMP) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
1 | P18502 (/IMP) |
|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | P18502 (/IMP) |
|
Eye-antennal disc morphogenesis GO:0007455
The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps.
|
1 | P18502 (/IMP) |
|
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
|
1 | P18502 (/IMP) |
|
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
|
1 | P18502 (/IMP) |
|
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
|
1 | P18502 (/IMP) |
|
Determination of genital disc primordium GO:0035225
Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two.
|
1 | P18502 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | P18502 (/IGI) |
|
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
|
1 | P18502 (/IGI) |
|
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
|
1 | P18502 (/IMP) |
|
Anterior/posterior lineage restriction, imaginal disc GO:0048099
Formation and/or maintenance of a lineage boundary between anterior and posterior compartments that cells cannot cross, thus separating the populations of cells in each compartment.
|
1 | P18502 (/TAS) |
|
Wing disc anterior/posterior pattern formation GO:0048100
The establishment, maintenance and elaboration of the anterior/posterior axis of the wing disc, a precursor to the wing.
|
1 | P18502 (/TAS) |
|
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
|
1 | P18502 (/IMP) |
|
Regulation of epithelial cell migration, open tracheal system GO:2000274
Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system.
|
1 | P18502 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P18502 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P18502 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P18502 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P18502 (/TAS) |
|
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
|
1 | P18502 (/IDA) |
|
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | P18502 (/IDA) |
|
Endocytic vesicle GO:0030139
A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
|
1 | P18502 (/IDA) |
