The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: sodium/hydrogen exchanger 9B2 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lithium:proton antiporter activity GO:0010348
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in).
3 B2RYK8 (/ISS) Q5BKR2 (/ISS) Q5R6B8 (/ISS)
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
3 Q7KTL6 (/IDA) Q95U27 (/IDA) Q9VM74 (/IDA)
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
3 Q7KTL6 (/IGI) Q95U27 (/IGI) Q9VM74 (/IGI)
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
3 B2RYK8 (/ISS) Q5BKR2 (/ISS) Q5R6B8 (/ISS)
Monovalent cation:proton antiporter activity GO:0005451
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out).
2 Q86UD5 (/TAS) Q86UD5 (/TAS)
Lithium:proton antiporter activity GO:0010348
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in).
2 Q86UD5 (/IMP) Q86UD5 (/IMP)
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2 A0A0B4K6G5 (/IDA) Q9VCS7 (/IDA)
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
2 Q86UD5 (/IMP) Q86UD5 (/IMP)
Potassium ion antiporter activity GO:0022821
Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
2 A0A0B4K6G5 (/IGI) Q9VCS7 (/IGI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q86UD5 (/IPI) Q86UD5 (/IPI)
Lithium:proton antiporter activity GO:0010348
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in).
1 Q5BKR2 (/ISO)
Sodium:proton antiporter activity GO:0015385
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).
1 Q5BKR2 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q5BKR2 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
6 B2RYK8 (/ISS) Q4R7S2 (/ISS) Q4ZJI4 (/ISS) Q5R6B8 (/ISS) Q86UD5 (/ISS) Q86UD5 (/ISS)
Renal sodium ion transport GO:0003096
The directed movement of sodium ions (Na+) by the kidney.
5 A0A0B4K6G5 (/IMP) Q7KTL6 (/IMP) Q95U27 (/IMP) Q9VCS7 (/IMP) Q9VM74 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
3 Q4ZJI4 (/TAS) Q86UD5 (/TAS) Q86UD5 (/TAS)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q86UD5 (/IDA) Q86UD5 (/IDA)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
2 A0A0B4K6G5 (/IMP) Q9VCS7 (/IMP)
Regulation of intracellular pH GO:0051453
Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
2 Q4R7S2 (/ISS) Q4ZJI4 (/ISS)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
2 A0A0B4K6G5 (/IMP) Q9VCS7 (/IMP)
Sodium ion transport GO:0006814
The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q5BKR2 (/ISO)
Flagellated sperm motility GO:0030317
Any process involved in the controlled movement of a flagellated sperm cell.
1 Q5BKR2 (/IMP)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 Q5BKR2 (/IDA)
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
1 Q5BKR2 (/IDA)
Positive regulation of osteoclast development GO:2001206
Any process that activates or increases the frequency, rate or extent of osteoclast development.
1 Q5BKR2 (/IDA)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
6 B2RYK8 (/ISS) Q4R7S2 (/ISS) Q4ZJI4 (/ISS) Q5R6B8 (/ISS) Q86UD5 (/ISS) Q86UD5 (/ISS)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
5 A0A0B4K6G5 (/IDA) Q7KTL6 (/IDA) Q95U27 (/IDA) Q9VCS7 (/IDA) Q9VM74 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q5BKR2 (/IDA) Q86UD5 (/IDA) Q86UD5 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 Q86UD5 (/TAS) Q86UD5 (/TAS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 A0A0B4K6G5 (/IDA) Q9VCS7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 B2RYK8 (/ISS) Q5R6B8 (/ISS)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
2 B2RYK8 (/ISS) Q5R6B8 (/ISS)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 B2RYK8 (/ISS) Q5R6B8 (/ISS)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
2 B2RYK8 (/ISS) Q5R6B8 (/ISS)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
2 Q86UD5 (/IDA) Q86UD5 (/IDA)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
2 Q5BKR2 (/ISS) Q5R6B8 (/ISS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 B2RYK8 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q5BKR2 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q5BKR2 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q4ZJI4 (/TAS)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q5BKR2 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 Q5BKR2 (/IDA)
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
1 Q5BKR2 (/IDA)
Sperm principal piece GO:0097228
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.
1 Q5BKR2 (/IMP)
Intracellular vesicle GO:0097708
Any vesicle that is part of the intracellular region.
1 B2RYK8 (/IDA)
Intracellular vesicle GO:0097708
Any vesicle that is part of the intracellular region.
1 Q5BKR2 (/ISO)
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