The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Gap junction channel protein cysteine-rich domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Gap junction protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Gap junction hemi-channel activity GO:0055077
A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.
5 Q503J6 (/IDA) Q8JFD2 (/IDA) Q9DF28 (/IDA) Q9DF76 (/IDA) Q9Y6H8 (/IDA)
Gap junction hemi-channel activity GO:0055077
A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.
5 P29414 (/ISS) P29415 (/ISS) P41987 (/ISS) Q64448 (/ISS) Q9TU17 (/ISS)
Gap junction channel activity GO:0005243
A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
4 P28236 (/ISS) P28236 (/ISS) P36381 (/ISS) P55917 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P29414 (/IPI) P36381 (/IPI) Q8K4Q9 (/IPI) Q8K4Q9 (/IPI)
Gap junction channel activity GO:0005243
A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
3 P29414 (/IDA) P48165 (/IDA) P48165 (/IDA)
Gap junction channel activity GO:0005243
A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes.
3 P28236 (/ISO) P28236 (/ISO) Q64448 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P29414 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q64448 (/ISO)
Gap junction hemi-channel activity GO:0055077
A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.
1 Q64448 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Gap junction-mediated intercellular transport GO:1990349
The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.
11 P28236 (/ISS) P28236 (/ISS) P29414 (/ISS) P29415 (/ISS) P36381 (/ISS) P41987 (/ISS) P55917 (/ISS) Q64448 (/ISS) Q8K4Q9 (/ISS) Q8K4Q9 (/ISS)
(1 more)
Cell communication by electrical coupling GO:0010644
The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.
4 B0R0X0 (/IMP) Q503E4 (/IMP) Q8AWR4 (/IMP) Q8JFD2 (/IMP)
Slow-twitch skeletal muscle fiber contraction GO:0031444
A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.
3 B0R0X0 (/IMP) Q503E4 (/IMP) Q8AWR4 (/IMP)
Gap junction-mediated intercellular transport GO:1990349
The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.
3 P48165 (/IDA) P48165 (/IDA) Q9Y6H8 (/IDA)
Gap junction-mediated intercellular transport GO:1990349
The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells.
3 P28236 (/ISO) P28236 (/ISO) Q64448 (/ISO)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
2 P28236 (/IMP) P28236 (/IMP)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2 Q8K4Q9 (/IDA) Q8K4Q9 (/IDA)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
2 P28236 (/ISO) P28236 (/ISO)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
2 P28236 (/IMP) P28236 (/IMP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 Q8K4Q9 (/IDA) Q8K4Q9 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 P28236 (/ISO) P28236 (/ISO)
Cardiac conduction system development GO:0003161
The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
1 Q8JFD2 (/IMP)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 Q8JFD2 (/IMP)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 P29414 (/IDA)
Response to pH GO:0009268
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 Q64448 (/ISO)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 P29414 (/IDA)
Response to hydrogen peroxide GO:0042542
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
1 Q64448 (/ISO)
Post-embryonic eye morphogenesis GO:0048050
The process, occurring after embryonic development, by which the anatomical structures of the eye are generated and organized. The eye is the organ of sight.
1 Q8JFD2 (/IMP)
Cardiac muscle tissue morphogenesis GO:0055008
The process in which the anatomical structures of cardiac muscle tissue are generated and organized.
1 Q8JFD2 (/IMP)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
13 P28236 (/ISS) P28236 (/ISS) P29414 (/ISS) P29415 (/ISS) P36381 (/ISS) P41987 (/ISS) Q503J6 (/ISS) Q64448 (/ISS) Q8JFD2 (/ISS) Q8K4Q9 (/ISS)
(3 more)
Connexin complex GO:0005922
An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.
7 P48165 (/IDA) P48165 (/IDA) P55917 (/IDA) Q8K4Q9 (/IDA) Q8K4Q9 (/IDA) Q9TU17 (/IDA) Q9Y6H8 (/IDA)
Connexin complex GO:0005922
An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.
7 P28236 (/ISS) P28236 (/ISS) P29414 (/ISS) P29415 (/ISS) P36381 (/ISS) P41987 (/ISS) Q64448 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 P48165 (/IDA) P48165 (/IDA) P55917 (/IDA) Q9TU17 (/IDA) Q9Y6H8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P28236 (/IDA) P28236 (/IDA) Q64448 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P28236 (/ISO) P28236 (/ISO) Q64448 (/ISO)
Connexin complex GO:0005922
An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.
3 Q503J6 (/IC) Q9DF28 (/IC) Q9DF76 (/IC)
Connexin complex GO:0005922
An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction.
3 P28236 (/ISO) P28236 (/ISO) Q64448 (/ISO)
Gap junction GO:0005921
A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.
2 P29414 (/IDA) Q64448 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q8K4Q9 (/IDA) Q8K4Q9 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P28236 (/ISO) P28236 (/ISO)
Gap junction GO:0005921
A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins.
1 Q64448 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P29414 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q64448 (/ISO)
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