Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

The transfer, from NAD, of ADP-ribose to protein amino acids.

The transfer, from NAD, of ADP-ribose to protein amino acids.

The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.

Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.

Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.

Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.

The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.

Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity.

Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.

Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.

Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

The transfer, from NAD, of ADP-ribose to protein amino acids.

The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.

The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA.

Any process that stops, prevents, or reduces the frequency, rate or extent of isotype switching.

Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.

Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

The ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.

The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.

The transfer, from NAD, of a single (mono) ADP-ribose molecule to protein amino acids.

Any process that stops, prevents or reduces the frequency, rate or extent of telomerase RNA reverse transcriptase activity.

Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred.

Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.

Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.

A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.