The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transcription factor DP
".
FunFam 1: Transcription factor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
18 |
Q08639 (/IPI)
Q08639 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
(8 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
17 |
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
Q14186 (/ISA)
(7 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
17 |
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
Q14186 (/ISM)
(7 more) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
16 |
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
Q14186 (/NAS)
(6 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
16 |
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
(6 more) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
16 |
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
Q14186 (/IPI)
(6 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
12 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(2 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
12 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(2 more) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
4 | Q14188 (/TAS) Q14188 (/TAS) Q14188 (/TAS) Q14188 (/TAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
4 | Q14188 (/NAS) Q14188 (/NAS) Q14188 (/NAS) Q14188 (/NAS) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
4 | Q14188 (/TAS) Q14188 (/TAS) Q14188 (/TAS) Q14188 (/TAS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
3 | Q08639 (/IDA) Q08639 (/IDA) Q64163 (/IDA) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
3 | Q08639 (/ISO) Q08639 (/ISO) Q64163 (/ISO) |
|
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
3 | Q08639 (/ISO) Q08639 (/ISO) Q64163 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
2 | Q08639 (/IDA) Q08639 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q5H9I0 (/IDA) |
There are 22 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
|
16 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(6 more) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
16 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(6 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
16 |
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
(6 more) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
16 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(6 more) |
|
Negative regulation of G0 to G1 transition GO:0070317
A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
|
16 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(6 more) |
|
Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740
Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway.
|
16 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(6 more) |
|
Negative regulation of fat cell proliferation GO:0070345
Any process that stops or decreases the rate or extent of fat cell proliferation.
|
13 |
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
Q14186 (/ISS)
(3 more) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
12 |
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(2 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | Q14188 (/IDA) Q14188 (/IDA) Q14188 (/IDA) Q14188 (/IDA) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q08639 (/IDA) Q08639 (/IDA) Q64163 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | Q08639 (/ISO) Q08639 (/ISO) Q64163 (/ISO) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | A0A0G2JXE8 (/IEP) B5DF82 (/IEP) |
|
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
|
2 | Q08639 (/IMP) Q08639 (/IMP) |
|
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
|
2 | Q08639 (/IDA) Q08639 (/IDA) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q08639 (/IDA) Q08639 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q08639 (/IGI) Q08639 (/IGI) |
|
Negative regulation of fat cell proliferation GO:0070345
Any process that stops or decreases the rate or extent of fat cell proliferation.
|
2 | Q08639 (/IMP) Q08639 (/IMP) |
|
Regulation of DNA biosynthetic process GO:2000278
Any process that modulates the frequency, rate or extent of DNA biosynthetic process.
|
2 | Q08639 (/IMP) Q08639 (/IMP) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
1 | Q5H9I0 (/IDA) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q5H9I0 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q64163 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q64163 (/ISS) |
There are 14 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
24 |
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
(14 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
24 |
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
A0A024RDY4 (/IDA)
(14 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
19 |
Q08639 (/TAS)
Q08639 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
Q14186 (/TAS)
(9 more) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
16 |
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
Q14186 (/IDA)
(6 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q08639 (/IDA) Q08639 (/IDA) Q5H9I0 (/IDA) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
3 | Q08639 (/ISO) Q08639 (/ISO) Q64163 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q08639 (/IDA) Q08639 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q08639 (/ISO) Q08639 (/ISO) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
2 | Q08639 (/IDA) Q08639 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q08639 (/ISO) Q08639 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q17QZ4 (/ISS) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | Q64163 (/TAS) |
|
Transcription factor complex GO:0005667
A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.
|
1 | Q64163 (/IC) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q17QZ4 (/ISS) |
