The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Claudin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
5 Q91Y55 (/ISS) Q925N4 (/ISS) Q925N4 (/ISS) Q9XT98 (/ISS) Q9Y5I7 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q91Y55 (/IPI) Q9Y5I7 (/IPI)
Magnesium ion transmembrane transporter activity GO:0015095
Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other.
1 Q9Y5I7 (/TAS)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338
The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.
5 Q91Y55 (/ISS) Q925N4 (/ISS) Q925N4 (/ISS) Q9XT98 (/ISS) Q9Y5I7 (/ISS)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q925N4 (/ISO) Q925N4 (/ISO)
Transepithelial transport GO:0070633
The directed movement of a substance from one side of an epithelium to the other.
2 Q925N4 (/ISO) Q925N4 (/ISO)
Cellular metal ion homeostasis GO:0006875
Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell.
1 Q9Y5I7 (/TAS)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
1 Q9Y5I7 (/TAS)
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q91Y55 (/IDA)
Transepithelial transport GO:0070633
The directed movement of a substance from one side of an epithelium to the other.
1 Q91Y55 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
5 Q91Y55 (/ISS) Q925N4 (/ISS) Q925N4 (/ISS) Q9XT98 (/ISS) Q9Y5I7 (/ISS)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
3 Q91Y55 (/IDA) Q925N4 (/IDA) Q925N4 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2 Q925N4 (/ISO) Q925N4 (/ISO)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
2 Q91Y55 (/TAS) Q9Y5I7 (/TAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 R4GLE8 (/IDA)
Mucin granule GO:0098594
A secretory granule that contains mucin.
1 R4GLE8 (/IDA)
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