The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Calcium release-activated calcium channel protein Orai
".
FunFam 1: Calcium release-activated calcium modulator 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
Q5M848 (/IPI)
Q8BWG9 (/IPI)
Q8BWG9 (/IPI)
Q96D31 (/IPI)
Q96D31 (/IPI)
Q96SN7 (/IPI)
Q96SN7 (/IPI)
Q96SN7 (/IPI)
Q96SN7 (/IPI)
Q9BRQ5 (/IPI)
(1 more) |
|
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
|
8 | Q5EAU0 (/ISS) Q5EAU0 (/ISS) Q5M848 (/ISS) Q5ZL05 (/ISS) Q6TLE6 (/ISS) Q6TLE6 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | Q96D31 (/IPI) Q96D31 (/IPI) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Store-operated calcium channel activity GO:0015279
A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores.
|
1 | Q5M848 (/IMP) |
There are 16 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
|
8 | Q5EAU0 (/ISS) Q5EAU0 (/ISS) Q5M848 (/ISS) Q5ZL05 (/ISS) Q6TLE6 (/ISS) Q6TLE6 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
8 | Q5EAU0 (/ISS) Q5EAU0 (/ISS) Q5M848 (/ISS) Q5ZL05 (/ISS) Q6TLE6 (/ISS) Q6TLE6 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
|
3 | Q5M848 (/IMP) Q6P8G8 (/IMP) Q6P8G8 (/IMP) |
|
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
|
3 | Q5M848 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
|
2 | Q8BWG9 (/IGI) Q8BWG9 (/IGI) |
|
Store-operated calcium entry GO:0002115
A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
|
2 | Q6TLE6 (/IMP) Q6TLE6 (/IMP) |
|
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Positive regulation of adenylate cyclase activity GO:0045762
Any process that activates or increases the frequency, rate or extent of adenylate cyclase activity.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q96D31 (/IMP) Q96D31 (/IMP) |
|
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Positive regulation of calcium ion transport GO:0051928
Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Mammary gland epithelium development GO:0061180
The process whose specific outcome is the progression of the mammary gland epithelium over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
2 | Q8BWG9 (/IMP) Q8BWG9 (/IMP) |
|
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
|
2 | Q8BWG9 (/IDA) Q8BWG9 (/IDA) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
8 | Q5EAU0 (/ISS) Q5EAU0 (/ISS) Q5M848 (/ISS) Q5ZL05 (/ISS) Q6TLE6 (/ISS) Q6TLE6 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
7 | Q6P8G8 (/IDA) Q6P8G8 (/IDA) Q8BH10 (/IDA) Q8BH10 (/IDA) Q8BH10 (/IDA) Q8BWG9 (/IDA) Q8BWG9 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | Q5EAU0 (/ISS) Q5EAU0 (/ISS) Q5ZL05 (/ISS) Q6TLE6 (/ISS) Q6TLE6 (/ISS) |
|
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
5 | B0BNI3 (/IDA) B0BNI3 (/IDA) B0BNI3 (/IDA) B2ZDP9 (/IDA) Q5M848 (/IDA) |
|
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
5 | Q8BH10 (/ISO) Q8BH10 (/ISO) Q8BH10 (/ISO) Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A0A0B4J2E8 (/IDA) A0A0B4J2E8 (/IDA) A0A0B4J2E8 (/IDA) A0A0B4J2E8 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q5M848 (/IDA) Q96D31 (/IDA) Q96D31 (/IDA) |
|
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
|
3 | Q5M848 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
3 | Q5M848 (/ISS) Q8BWG9 (/ISS) Q8BWG9 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q96D31 (/HDA) Q96D31 (/HDA) |
|
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
2 | Q8BWG9 (/IDA) Q8BWG9 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q8BWG9 (/IPI) Q8BWG9 (/IPI) |
|
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
2 | Q96D31 (/IDA) Q96D31 (/IDA) |
|
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
2 | Q8BWG9 (/ISO) Q8BWG9 (/ISO) |