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CATH Superfamily 1.20.1340.10

dopa decarboxylase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
dopa decarboxylase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Histidine decarboxylase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aromatic-L-amino-acid decarboxylase. [EC: 4.1.1.28]
(1) L-dopa = dopamine + CO(2). (2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).
  • Also acts on other aromatic L-amino acids, including L-tryptophan.
  • Formerly EC 4.1.1.26 and EC 4.1.1.27.
 15 A0A0S2Z3N4 A0A0S2Z3N4 F0JAJ6 F0JAJ6 O88533 O88533 O96567 P05031 P05031 P14173
(5 more...)
Tyrosine decarboxylase. [EC: 4.1.1.25]
L-tyrosine = tyramine + CO(2).
  • The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine.
 10 A0A0E0N310 A0A0E0N310 F6L7A0 F6L7A0 Q8RY79 Q8RY79 Q94EE9 Q94EE9 Q95ZS2 Q9M0G4
Histidine decarboxylase. [EC: 4.1.1.22]
L-histidine = histamine + CO(2).
    		 8 I0B8M2 I0B8M2 P16453 P19113 P23738 Q05733 Q05733 Q5EA83
    3,4-dihydroxyphenylacetaldehyde synthase. [EC: 4.1.1.107]
    L-dopa + O(2) + H(2)O = 3,4-dihydroxyphenylacetaldehyde + CO(2) + NH(3) + H(2)O(2).
    • The enzyme, isolated from the mosquito Aedes aegypti, catalyzes the production of 3,4-dihydroxylphenylacetaldehyde directly from L-dopa.
    • Dopamine is not formed as an intermediate (cf. EC 4.1.1.28).
    • The enzyme is specific for L-dopa and does not react with other aromatic amino acids with the exception of a low activity with alpha- methyl-L-dopa.
    		 5 H5V873 H5V873 P18486 P18486 Q16S21
    L-tryptophan decarboxylase. [EC: 4.1.1.105]
    L-tryptophan = tryptamine + CO(2).
    • The enzyme has been characterized from bacteria, plants, and fungi.
    • Unlike EC 4.1.1.28 this enzyme is specific for L-typtophan.
    		 2 P93082 P93083
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