The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Sphingolipid long chain base-responsive pil1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
13 P53252 (/IPI) P53252 (/IPI) P53252 (/IPI) P53252 (/IPI) P53252 (/IPI) P53252 (/IPI) P53252 (/IPI) Q12230 (/IPI) Q12230 (/IPI) Q12230 (/IPI)
(3 more)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
13 P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) Q12230 (/IDA) Q12230 (/IDA) Q12230 (/IDA)
(3 more)
Protein kinase inhibitor activity GO:0004860
Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
13 P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) Q12230 (/IMP) Q12230 (/IMP) Q12230 (/IMP)
(3 more)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
13 P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) Q12230 (/IMP) Q12230 (/IMP) Q12230 (/IMP)
(3 more)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
13 P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) Q12230 (/IMP) Q12230 (/IMP) Q12230 (/IMP)
(3 more)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
9 P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) Q5B2L3 (/IMP) Q5B2L3 (/IMP)
Eisosome assembly GO:0070941
The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.
8 O74960 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP)
Protein localization to eisosome filament GO:0097446
A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.
7 P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP) P53252 (/IMP)
Eisosome assembly GO:0070941
The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.
4 A0A1D8PDD1 (/IGI) A0A1D8PDD1 (/IGI) Q59KV8 (/IGI) Q59KV8 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Eisosome assembly GO:0070941
The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.
3 O74960 (/IDA) Q5B2L3 (/IDA) Q5B2L3 (/IDA)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 O14128 (/ISO) O74960 (/ISO)
Negative regulation of sphingolipid biosynthetic process GO:0090155
Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
2 Q5B2L3 (/IMP) Q5B2L3 (/IMP)
Ascospore-type prospore-specific spindle pole body remodeling GO:0031322
A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP).
1 O94756 (/IMP)
Eisosome assembly GO:0070941
The aggregation, arrangement and bonding together of a set of components to form an eisosome, a cell part that is composed of the eisosome membrane and eisosome filaments. The eisosome membrane, also called the MCC domain, is a furrow-like plasma membrane sub-domain with associated integral transmembrane proteins. The eisosome filaments form a scaffolding lattice on the cytoplasmic face of the membrane.
1 O14128 (/ISO)
Lipid droplet localization to prospore membrane leading edge GO:0140043
Any process in which a lipid droplet is transported to, or maintained to the prospore membrane leading edge.
1 O94756 (/EXP)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eisosome GO:0032126
A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.
20 A0A1D8PDD1 (/IDA) A0A1D8PDD1 (/IDA) O74960 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA) P53252 (/IDA)
(10 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
13 P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) Q12230 (/HDA) Q12230 (/HDA) Q12230 (/HDA)
(3 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
13 P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) Q12230 (/HDA) Q12230 (/HDA) Q12230 (/HDA)
(3 more)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
13 P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) Q12230 (/HDA) Q12230 (/HDA) Q12230 (/HDA)
(3 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
13 P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) Q12230 (/HDA) Q12230 (/HDA) Q12230 (/HDA)
(3 more)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
13 P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) P53252 (/HDA) Q12230 (/HDA) Q12230 (/HDA) Q12230 (/HDA)
(3 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Eisosome GO:0032126
A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.
3 G4NE61 (/ISS) G4NE61 (/ISS) G4NE61 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q6FKT0 (/IDA) Q6FKT0 (/IDA)
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 Q5B2L3 (/IDA) Q5B2L3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 C8V645 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O14128 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 C8V645 (/IDA)
Eisosome GO:0032126
A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.
1 O14128 (/ISO)
Meiotic spindle pole body GO:0035974
The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.
1 O94756 (/IDA)
Eisosome filament GO:0036286
A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.
1 O74960 (/IDA)
Ascus membrane GO:0036362
A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi.
1 O74960 (/IDA)
Prospore membrane leading edge GO:0070056
The region of the prospore membrane that extends to surround the spore nucleus; coated with specific proteins that are thought to play a role in prospore membrane organization.
1 O94756 (/IDA)
Prospore membrane spindle pole body attachment site GO:0070057
The region of the prospore membrane to which the spindle pole body (SPB) is anchored; the prospore membrane extends from the SPB attachment site to surround the spore nucleus.
1 O94756 (/IDA)
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