The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35: Sorting nexin 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
3 A1A4L0 (/ISS) Q5R4C2 (/ISS) Q91YJ2 (/ISS)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
2 O95219 (/IDA) O95219 (/IDA)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
2 O95219 (/IDA) O95219 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O95219 (/IPI) O95219 (/IPI)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
2 O95219 (/IMP) O95219 (/IMP)
Transferrin receptor binding GO:1990459
Interacting selectively and non-covalently with the transferrin receptor.
2 O95219 (/IDA) O95219 (/IDA)
Leptin receptor binding GO:1990460
Interacting selectively and non-covalently with the leptin receptor.
2 O95219 (/IDA) O95219 (/IDA)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 Q91YJ2 (/ISO)
Insulin receptor binding GO:0005158
Interacting selectively and non-covalently with the insulin receptor.
1 Q91YJ2 (/ISO)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 Q91YJ2 (/ISO)
Transferrin receptor binding GO:1990459
Interacting selectively and non-covalently with the transferrin receptor.
1 Q91YJ2 (/ISO)
Leptin receptor binding GO:1990460
Interacting selectively and non-covalently with the leptin receptor.
1 Q91YJ2 (/ISO)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 A1A4L0 (/ISS) Q5R4C2 (/ISS) Q91YJ2 (/ISS)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
3 A1A4L0 (/ISS) Q5R4C2 (/ISS) Q91YJ2 (/ISS)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O95219 (/IMP) O95219 (/IMP)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
2 O95219 (/IMP) O95219 (/IMP)
Positive regulation of histamine secretion by mast cell GO:1903595
Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell.
2 O95219 (/IMP) O95219 (/IMP)
Protein transport GO:0015031
The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q91YJ2 (/ISO)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
1 Q91YJ2 (/ISO)
Positive regulation of histamine secretion by mast cell GO:1903595
Any process that activates or increases the frequency, rate or extent of histamine secretion by mast cell.
1 Q91YJ2 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
3 A1A4L0 (/ISS) Q5R4C2 (/ISS) Q91YJ2 (/ISS)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
3 A1A4L0 (/ISS) Q5R4C2 (/ISS) Q91YJ2 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O95219 (/IDA) O95219 (/IDA)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
2 O95219 (/IDA) O95219 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O95219 (/IDA) O95219 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 O95219 (/IDA) O95219 (/IDA)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
2 O95219 (/IDA) O95219 (/IDA)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
2 O95219 (/IDA) O95219 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 O95219 (/IDA) O95219 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q91YJ2 (/ISO)
Cytoplasmic dynein complex GO:0005868
Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains.
1 Q91YJ2 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q91YJ2 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q91YJ2 (/ISO)
SNARE complex GO:0031201
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.
1 Q91YJ2 (/ISO)
Early endosome membrane GO:0031901
The lipid bilayer surrounding an early endosome.
1 Q91YJ2 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q91YJ2 (/ISO)
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