The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 33: Sorting nexin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q8I4E2 (/IPI) Q8WV41 (/IPI) Q91ZR2 (/IPI) Q96RF0 (/IPI)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
2 Q8I4E2 (/IDA) Q96RF0 (/IDA)
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
2 Q8I4E2 (/IDA) Q91ZR2 (/IDA)
Phosphatidylinositol-4,5-bisphosphate binding GO:0005546
Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions.
1 Q91ZR2 (/ISO)
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
1 Q8I4E2 (/IDA)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q8I4E2 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8WV41 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q4VAA7 (/ISO)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
1 Q8I4E2 (/IPI)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
1 Q8I4E2 (/IPI)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
5 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS) Q91ZR2 (/ISS)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Endosome organization GO:0007032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Cleavage furrow formation GO:0036089
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Macropinocytosis GO:0044351
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
2 Q8WV41 (/IMP) Q96RF0 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
2 Q4VAA7 (/ISO) Q91ZR2 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q8WV41 (/IMP) Q96RF0 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
2 Q4VAA7 (/ISO) Q91ZR2 (/ISO)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 Q8WV41 (/IMP) Q96RF0 (/IMP)
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
2 Q4VAA7 (/ISO) Q91ZR2 (/ISO)
Cleavage furrow formation GO:0036089
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
2 Q8WV41 (/IMP) Q96RF0 (/IMP)
Cleavage furrow formation GO:0036089
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.
2 Q4VAA7 (/ISO) Q91ZR2 (/ISO)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 Q96RF0 (/IDA)
Endosome organization GO:0007032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
1 Q8WV41 (/IMP)
Endosome organization GO:0007032
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes.
1 Q4VAA7 (/ISO)
Protein import GO:0017038
The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
1 Q8WV41 (/IDA)
Protein import GO:0017038
The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
1 Q4VAA7 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q96RF0 (/IDA)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q91ZR2 (/ISO)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
1 Q91ZR2 (/ISS)
Macropinocytosis GO:0044351
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
1 Q8WV41 (/IMP)
Macropinocytosis GO:0044351
An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.
1 Q4VAA7 (/ISO)
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
1 Q8WV41 (/IDA)
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
1 Q4VAA7 (/ISO)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
1 Q8WV41 (/IDA)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
1 Q4VAA7 (/ISO)
Phagosome maturation involved in apoptotic cell clearance GO:0090386
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.
1 Q8I4E2 (/IMP)
Phagolysosome assembly involved in apoptotic cell clearance GO:0090387
The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.
1 Q8I4E2 (/IMP)
Phagosome-lysosome fusion involved in apoptotic cell clearance GO:0090389
The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance.
1 Q8I4E2 (/IGI)
Phagosome-lysosome fusion involved in apoptotic cell clearance GO:0090389
The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance.
1 Q8I4E2 (/IMP)
Execution phase of apoptosis GO:0097194
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
1 Q8I4E2 (/IMP)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
1 Q8WV41 (/IDA)
Plasma membrane tubulation GO:0097320
A membrane tubulation process occurring in a plasma membrane.
1 Q4VAA7 (/ISO)
Negative regulation of protein localization to cell surface GO:2000009
Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.
1 Q8WV41 (/IDA)
Negative regulation of protein localization to cell surface GO:2000009
Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface.
1 Q4VAA7 (/ISO)
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
1 Q8WV41 (/IDA)
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
1 Q4VAA7 (/ISO)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
4 Q28GP7 (/ISS) Q4VAA7 (/ISS) Q6NRL2 (/ISS) Q6NRL2 (/ISS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q8WV41 (/IDA) Q96RF0 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
2 Q4VAA7 (/ISO) Q91ZR2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8I4E2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WV41 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q4VAA7 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8WV41 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q4VAA7 (/ISO)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q8WV41 (/IDA)
Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q4VAA7 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q91ZR2 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q96RF0 (/IDA)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q91ZR2 (/ISO)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 Q91ZR2 (/ISS)
Early phagosome GO:0032009
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.
1 Q8I4E2 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q91ZR2 (/IDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 Q8I4E2 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q96RF0 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q96RF0 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q91ZR2 (/ISO)
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