The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Arfaptin homology (AH) domain/BAR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Rho GTPase-activating protein 26

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 A1A4S6 (/IPI) A1A4S6 (/IPI) P0CAX5 (/IPI) Q6Y5D8 (/IPI) Q6ZQ82 (/IPI) Q99J31 (/IPI) Q9UNA1 (/IPI)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
5 A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) Q6Y5D8 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
2 Q9VXQ2 (/ISM) X2JDY8 (/ISM)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 O60890 (/IDA) Q9UNA1 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 Q6ZQ82 (/ISO) Q99J31 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 Q9VXQ2 (/ISS) X2JDY8 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q99J31 (/IDA)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q99J31 (/IMP)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 Q9UNA1 (/NAS)
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
1 O60890 (/TAS)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
1 P0CAX5 (/IPI)
Ionotropic glutamate receptor binding GO:0035255
Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.
1 Q99J31 (/ISO)
Ubiquitin-dependent protein binding GO:0140036
Interacting selectively and non-covalently with a protein upon ubiquitination of the target protein.
1 X2JDY8 (/IDA)

There are 45 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell junction assembly GO:0034329
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
10 P0CAX5 (/ISS) Q7YQL5 (/ISS) Q7YQL5 (/ISS) Q7YQL5 (/ISS) Q7YQL5 (/ISS) Q7YQL6 (/ISS) Q7YQL6 (/ISS) Q7YQL6 (/ISS) Q7YQL6 (/ISS) Q99J31 (/ISS)
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
10 P0CAX5 (/ISS) Q7YQL5 (/ISS) Q7YQL5 (/ISS) Q7YQL5 (/ISS) Q7YQL5 (/ISS) Q7YQL6 (/ISS) Q7YQL6 (/ISS) Q7YQL6 (/ISS) Q7YQL6 (/ISS) Q99J31 (/ISS)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
4 A1A4S6 (/TAS) A1A4S6 (/TAS) O60890 (/TAS) Q9UNA1 (/TAS)
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
4 A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA) A6NI28 (/IDA)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
2 Q9VXQ2 (/ISM) X2JDY8 (/ISM)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
1 X2JDY8 (/IMP)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
1 O60890 (/TAS)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
1 Q6Y5D8 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 O60890 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q9UNA1 (/NAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O60890 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 O60890 (/TAS)
Cerebellar granule cell differentiation GO:0021707
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
1 O60890 (/IMP)
Cerebellar granule cell differentiation GO:0021707
The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.
1 Q99J31 (/ISO)
Cerebral cortex neuron differentiation GO:0021895
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
1 O60890 (/IMP)
Cerebral cortex neuron differentiation GO:0021895
The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.
1 Q99J31 (/ISO)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q99J31 (/IDA)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
1 Q9UNA1 (/NAS)
Regulation of endocytosis GO:0030100
Any process that modulates the frequency, rate or extent of endocytosis.
1 Q99J31 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 O60890 (/IMP)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
1 Q99J31 (/ISO)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 O60890 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 Q99J31 (/ISO)
Cell junction assembly GO:0034329
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
1 O60890 (/IMP)
Cell junction assembly GO:0034329
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.
1 Q99J31 (/ISO)
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
1 O60890 (/IMP)
Regulation of Rho protein signal transduction GO:0035023
Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
1 Q99J31 (/ISO)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
1 X2JDY8 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q6Y5D8 (/IMP)
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
1 O60890 (/IMP)
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
1 Q99J31 (/ISO)
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
1 Q99J31 (/IGI)
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
1 Q99J31 (/IMP)
Cell morphogenesis involved in neuron differentiation GO:0048667
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
1 O60890 (/IMP)
Cell morphogenesis involved in neuron differentiation GO:0048667
The process in which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
1 Q99J31 (/ISO)
Regulation of synaptic transmission, glutamatergic GO:0051966
Any process that modulates the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 Q99J31 (/IMP)
Maintenance of postsynaptic specialization structure GO:0098880
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
1 P0CAX5 (/EXP)
Maintenance of postsynaptic specialization structure GO:0098880
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
1 P0CAX5 (/IDA)
Maintenance of postsynaptic specialization structure GO:0098880
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
1 P0CAX5 (/IMP)
Maintenance of postsynaptic specialization structure GO:0098880
A process which maintains the organization and the arrangement of proteins in the presynaptic specialization.
1 Q99J31 (/ISO)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 O60890 (/EXP)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 O60890 (/IDA)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 O60890 (/IMP)
Regulation of postsynaptic neurotransmitter receptor internalization GO:0099149
Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse.
1 Q99J31 (/ISO)
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
1 Q99J31 (/IDA)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 A1A4S6 (/TAS) A1A4S6 (/TAS) O60890 (/TAS) Q6Y5D8 (/TAS) Q9UNA1 (/TAS)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 O60890 (/EXP) P0CAX5 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 O60890 (/IDA) P0CAX5 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 O60890 (/IMP) P0CAX5 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q99J31 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6Y5D8 (/IMP)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q99J31 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q99J31 (/IDA)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 X2JDY8 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 Q99J31 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q99J31 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q99J31 (/ISO)
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