The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 53: Rho family-interacting cell polarization regulator...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
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14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
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1 | Q7TP54 (/ISS) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
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1 | Q7TP54 (/ISS) |
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Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
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1 | Q7TP54 (/ISS) |
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Negative regulation of Rho protein signal transduction GO:0035024
Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
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1 | Q7TP54 (/ISS) |
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Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
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1 | Q7TP54 (/ISS) |
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Positive regulation of filopodium assembly GO:0051491
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
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1 | Q7TP54 (/ISS) |
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Positive regulation of neutrophil chemotaxis GO:0090023
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
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1 | Q7TP54 (/ISS) |
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Positive regulation of myoblast fusion GO:1901741
Any process that activates or increases the frequency, rate or extent of myoblast fusion.
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1 | Q7TP54 (/ISS) |
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Negative regulation of establishment of T cell polarity GO:1903904
Any process that stops, prevents or reduces the frequency, rate or extent of establishment of T cell polarity.
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1 | Q7TP54 (/ISS) |
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Negative regulation of protein localization to cell leading edge GO:1905872
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge.
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1 | Q7TP54 (/ISS) |
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Cellular response to chemokine GO:1990869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
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1 | Q7TP54 (/ISS) |
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Regulation of establishment of cell polarity GO:2000114
Any process that modulates the frequency, rate or extent of establishment of cell polarity.
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1 | Q7TP54 (/ISS) |
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Positive regulation of neutrophil extravasation GO:2000391
Any process that activates or increases the frequency, rate or extent of neutrophil extravasation.
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1 | Q7TP54 (/ISS) |
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Negative regulation of T cell migration GO:2000405
Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.
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1 | Q7TP54 (/ISS) |
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Negative regulation of Rho guanyl-nucleotide exchange factor activity GO:2001107
Any process that stops, prevents or reduces the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
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1 | Q7TP54 (/ISS) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
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1 | Q7TP54 (/ISS) |
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Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
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1 | Q7TP54 (/ISS) |
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Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
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1 | Q7TP54 (/IDA) |
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Filopodium GO:0030175
Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
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1 | Q7TP54 (/ISS) |
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Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
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1 | Q7TP54 (/IDA) |
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Stereocilium membrane GO:0060171
The portion of the plasma membrane surrounding a stereocilium.
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1 | Q7TP54 (/IDA) |