The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Ferritin, mitochondrial

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 O16453 (/IPI) P02794 (/IPI) P02794 (/IPI) P02794 (/IPI) P02794 (/IPI) P19132 (/IPI) Q6NZ44 (/IPI) Q9TYS3 (/IPI)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
5 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) Q9D5H4 (/TAS)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
2 P09528 (/IDA) P09528 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O16453 (/IPI) Q9TYS3 (/IPI)
Ferroxidase activity GO:0004322
Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
1 Q9D5H4 (/TAS)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
18 O46414 (/ISS) P02794 (/ISS) P02794 (/ISS) P02794 (/ISS) P02794 (/ISS) P08267 (/ISS) P08267 (/ISS) P09528 (/ISS) P09528 (/ISS) P18685 (/ISS)
(8 more)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
18 O46414 (/ISS) P02794 (/ISS) P02794 (/ISS) P02794 (/ISS) P02794 (/ISS) P08267 (/ISS) P08267 (/ISS) P09528 (/ISS) P09528 (/ISS) P18685 (/ISS)
(8 more)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
6 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) Q8N4E7 (/TAS) Q9D5H4 (/TAS)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
5 P02794 (/IDA) P02794 (/IDA) P02794 (/IDA) P02794 (/IDA) P19132 (/IDA)
Intracellular sequestering of iron ion GO:0006880
The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
4 P02794 (/IDA) P02794 (/IDA) P02794 (/IDA) P02794 (/IDA)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
4 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS)
Iron ion transport GO:0006826
The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P09528 (/IDA) P09528 (/IDA)
Intracellular sequestering of iron ion GO:0006880
The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system.
2 P09528 (/ISO) P09528 (/ISO)
Negative regulation of fibroblast proliferation GO:0048147
Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
2 P09528 (/ISO) P09528 (/ISO)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q8N4E7 (/IDA)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 O16453 (/IMP)
Cellular iron ion homeostasis GO:0006879
Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
1 Q9D5H4 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q8N4E7 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q9D5H4 (/ISO)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
1 C1BEL9 (/IDA)
Defense response to Gram-positive bacterium GO:0050830
Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism.
1 Q9TYS3 (/IEP)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
1 Q8N4E7 (/IDA)
Positive regulation of lyase activity GO:0051349
Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
1 Q9D5H4 (/ISO)
Negative regulation of necrotic cell death GO:0060547
Any process that decreases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents.
1 P19132 (/IMP)
Positive regulation of succinate dehydrogenase activity GO:1904231
Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.
1 Q8N4E7 (/IGI)
Positive regulation of succinate dehydrogenase activity GO:1904231
Any process that activates or increases the frequency, rate or extent of succinate dehydrogenase activity.
1 Q9D5H4 (/ISO)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
1 Q8N4E7 (/IGI)
Positive regulation of aconitate hydratase activity GO:1904234
Any process that activates or increases the frequency, rate or extent of aconitate hydratase activity.
1 Q9D5H4 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P09528 (/TAS) P09528 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P02794 (/HDA) P02794 (/HDA) P02794 (/HDA) P02794 (/HDA) Q8N4E7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS)
Intracellular ferritin complex GO:0008043
A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.
4 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS)
Autolysosome GO:0044754
A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.
4 P02794 (/IDA) P02794 (/IDA) P02794 (/IDA) P02794 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P02794 (/HDA) P02794 (/HDA) P02794 (/HDA) P02794 (/HDA)
Tertiary granule lumen GO:1904724
Any membrane-enclosed lumen that is part of a tertiary granule.
4 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
4 P02794 (/TAS) P02794 (/TAS) P02794 (/TAS) P02794 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P09528 (/HDA) P09528 (/HDA) Q9D5H4 (/HDA)
Autolysosome GO:0044754
A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.
2 P09528 (/ISO) P09528 (/ISO)
Endocytic vesicle lumen GO:0071682
The volume enclosed by the membrane of an endocytic vesicle.
2 P09528 (/TAS) P09528 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D5H4 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 Q8N4E7 (/TAS)
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