The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Interleukin-7

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
7 P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P26895 (/ISS) P56478 (/ISS) Q28540 (/ISS)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
6 P10168 (/IDA) P10168 (/IDA) P13232 (/IDA) P13232 (/IDA) P13232 (/IDA) P13232 (/IDA)
Interleukin-7 receptor binding GO:0005139
Interacting selectively and non-covalently with the interleukin-7 receptor.
4 P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P13232 (/IPI) P13232 (/IPI) P13232 (/IPI) P13232 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
3 P26895 (/ISS) P56478 (/ISS) Q28540 (/ISS)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
2 P10168 (/ISO) P10168 (/ISO)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
2 P10168 (/IDA) P10168 (/IDA)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
7 P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P26895 (/ISS) P56478 (/ISS) Q28540 (/ISS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
7 P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P26895 (/ISS) P56478 (/ISS) Q28540 (/ISS)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
7 P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P26895 (/ISS) P56478 (/ISS) Q28540 (/ISS)
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
7 P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P13232 (/ISS) P26895 (/ISS) P56478 (/ISS) Q28540 (/ISS)
Positive regulation of cytokine-mediated signaling pathway GO:0001961
Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
4 P13232 (/IDA) P13232 (/IDA) P13232 (/IDA) P13232 (/IDA)
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
4 P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
4 P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
4 P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
4 P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P13232 (/IDA) P13232 (/IDA) P13232 (/IDA) P13232 (/IDA)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
4 P13232 (/IDA) P13232 (/IDA) P13232 (/IDA) P13232 (/IDA)
Interleukin-7-mediated signaling pathway GO:0038111
A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
4 P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Positive regulation of cytokine-mediated signaling pathway GO:0001961
Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.
2 P10168 (/ISO) P10168 (/ISO)
T cell lineage commitment GO:0002360
The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.
2 P10168 (/IMP) P10168 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P10168 (/IDA) P10168 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P10168 (/IMP) P10168 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P10168 (/IDA) P10168 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P10168 (/ISO) P10168 (/ISO)
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
2 P10168 (/IDA) P10168 (/IDA)
Positive regulation of B cell proliferation GO:0030890
Any process that activates or increases the rate or extent of B cell proliferation.
2 P10168 (/IGI) P10168 (/IGI)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
2 P10168 (/ISO) P10168 (/ISO)
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
2 P10168 (/IDA) P10168 (/IDA)
Bone resorption GO:0045453
The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.
2 P10168 (/IDA) P10168 (/IDA)
Positive regulation of B cell differentiation GO:0045579
Any process that activates or increases the frequency, rate or extent of B cell differentiation.
2 P10168 (/IDA) P10168 (/IDA)
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
2 P10168 (/IDA) P10168 (/IDA)
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
2 P10168 (/IGI) P10168 (/IGI)
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
2 P10168 (/IMP) P10168 (/IMP)
Homeostasis of number of cells within a tissue GO:0048873
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
2 P10168 (/IMP) P10168 (/IMP)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P10168 (/IDA) P10168 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
2 P10168 (/IDA) P10168 (/IDA)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
2 P10168 (/IDA) P10168 (/IDA)
Response to X-ray GO:0010165
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz).
1 P56478 (/IEP)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 P56478 (/IEP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
6 P10168 (/TAS) P10168 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS) P13232 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 P13232 (/IDA) P13232 (/IDA) P13232 (/IDA) P13232 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
4 P13232 (/HDA) P13232 (/HDA) P13232 (/HDA) P13232 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P10168 (/ISO) P10168 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P10168 (/IDA) P10168 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...